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Moumoujus

SETARIA ITALICA SEED EXTRACT.

Valuable / HUMECTANT, SKIN CONDITIONING

Setaria Italica Seed Extract, derived from foxtail millet, is a multi-functional ingredient recognized for its robust antioxidant capabilities, safeguarding skin from oxidative stress. It proficiently acts as a humectant, drawing and retaining vital moisture, and additionally serves as a skin conditioning agent to promote overall skin health and suppleness.

Summary

Antioxidant Humectant Skin-Conditioning Emollient

Science

Mechanism of Action

This extract primarily functions as a potent antioxidant, attributed to its rich profile of bioactive compounds including phenolics, flavonoids, tannins, and tocopherols, which effectively scavenge free radicals and prevent cellular damage. It also provides significant humectant benefits, attracting and holding moisture to ensure optimal skin hydration. Furthermore, its emollient properties contribute to a smoother, softer skin texture, while research indicates potential anti-inflammatory and immunity-modulating effects on the skin.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Aqueous extracts demonstrated significantly higher radical scavenging activity at lower concentrations (0.4–1.2 mg) compared to other solvents.
  2. 02 Methanolic extracts exhibited considerably higher radical scavenging activity at elevated concentrations (1.6–2.0 mg) compared to ethanol and aqueous extracts.
  3. 03 A specific polysaccharide (FM-D1) from the extract achieved maximum antioxidant capacity and the highest DPPH radical scavenging ability.
  4. 04 The polysaccharide FM-D1 notably reduced the secretion levels of pro-inflammatory markers TNF-α and IL-6, indicating an anti-inflammatory effect.
  5. 05 Further studies with polysaccharide FM-D1 showed a significant decrease in TNF-α, IL-6, and NO content, suggesting both anti-inflammatory and immunostimulatory benefits.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

No specific optimal pH range for stability in skincare formulations has been identified. However, its diverse solubility across polar (water, methanol, ethanol) and semi-polar/non-polar solvents indicates the presence of components with varied solubilities, suggesting versatility in formulation.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

While generally regarded as safe in food and nutraceutical applications, Setaria Italica Seed Extract has not been specifically reviewed for topical use by the CIR, SCCS, or FDA. There is a documented potential for allergic reactions in sensitive individuals due to cross-reactivity with other grains, although cosmetic ingredients in Europe undergo stringent safety assessments.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Setaria Italica Seed Extract is a valuable ingredient, offering broad-spectrum antioxidant protection, superior hydration, and promising anti-inflammatory benefits with excellent skin compatibility.

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