Science
Mechanism of Action
The primary mode of action for Sequoiadendron Giganteum Callus Culture Extract lies with its key active component, shikimic acid. This compound adeptly reprograms human dermal fibroblasts into multipotent skin-derived precursor cells (SKPs/NeuSKPCs). This intricate process is orchestrated through the mannose receptor, which activates the MYD88-P38 MAPK-CREB pathway, subsequently inducing mesenchymal-to-epithelial transition (MET) and nestin expression. These cellular activities collectively promote comprehensive skin repair, facilitate wound healing, support dermal reconstruction, and significantly enhance natural collagen production. Additionally, the extract demonstrates notable antioxidant capabilities, further safeguarding skin integrity.
Research
Clinical Evidence
Low confidenceN/A
Key findings
- 01 Treatment of human dermal fibroblasts for 7 days induced cellular stemness, upregulated pluripotent stem cell markers (OCT4, NANOG, Sox2), and significantly promoted colony formation, indicating regenerative potential.
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
This ingredient has not been specifically reviewed by the Cosmetic Ingredient Review (CIR) or the Scientific Committee on Consumer Safety (SCCS). Its absence from the FDA's Voluntary Cosmetics Registration Program prior to 2019 suggests minimal historical usage in cosmetics, thereby reducing its priority for formal review. While specific safety data is limited, general evidence from Sequoia callus cultures suggests a low toxicity profile for normal cells.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Sequoiadendron Giganteum Callus Culture Extract presents significant promise as a regenerative and protective ingredient, leveraging unique cellular reprogramming capabilities for advanced skin care.
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