Science
Mechanism of Action
This extract operates via multiple pathways to enhance skin well-being. It effectively inhibits the proliferation of Propionibacterium acnes, a primary bacterium implicated in acne pathogenesis, while simultaneously mitigating inflammatory responses. Research indicates its ability to suppress nitric oxide (NO) production, downregulate the expression of iNOS/IL-1beta, and reduce inflammatory cytokines such as IL-1alpha and IL-8. These actions are largely attributed to its rich composition of bioactive biflavonoids, including amentoflavone, which contribute to its diverse beneficial activities.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 In cell models, concentrations below 50 microg/mL were observed to be non-cytotoxic.
- 02 Concentrations exceeding 100 microg/mL demonstrated non-antibiotic antimicrobial activity against Propionibacterium acnes.
- 03 Exhibited anti-acne activity by inhibiting inflammatory responses and Propionibacterium acnes. It reduced nitric oxide (NO) production, iNOS/IL-1beta expression, and the inflammatory cytokines IL-1alpha and IL-8. A dose-dependent antioxidant effect was also observed.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The extract is soluble in polar solvents, with ethanol (70%) and water commonly used for extraction, indicating good dispersibility in aqueous and hydroalcoholic systems.
Safety
Safety Profile
No specific safety assessments from CIR, SCCS, or FDA are available. However, in vitro studies showed no cytotoxicity at concentrations under 50 microg/mL, suggesting a low potential for cellular toxicity at tested levels.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Selaginella involvens extract is a valuable ingredient, offering multi-targeted benefits for skin clarity, reduction of inflammation, and protection against oxidative stress, especially beneficial for oily and sensitive skin types.
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References
Sources