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SEDUM TAKESIMENSE LEAF/STEM EXTRACT.

Insufficient Data / ANTIMICROBIAL, SKIN CONDITIONING

Sedum Takesimense Leaf/Stem Extract is a botanical active derived from the *Sedum takesimense* plant, recognized for its diverse properties. It serves as a skin conditioning agent and exhibits antimicrobial capabilities, attributed to its abundant antioxidant compounds.

Antimicrobial Skin Conditioning Antioxidant Neuroprotective

Science

The extract's biological activity is primarily driven by its phenolic constituents and flavonoids, potent antioxidants evidenced by DPPH and ABTS radical scavenging. In specific *in vitro* studies on neuronal cells, a water extract demonstrated significant neuroprotective potential by inhibiting neural apoptosis, reducing endoplasmic reticulum (ER) stress, and optimizing mitochondrial function.


Research

Low confidence
Effective range 10–200%
Optimal

N/A


Transparency

Not commonly dusted

The Formula

Solubility
Water
Optimal pH N/A
0 7 14

Conflicts

  • Increased likelihood of irritation when combined with other problematic ingredients.

Safety

CIR Status
Not reviewed
Sensitization risk Moderate

No direct CIR, SCCS, or FDA safety assessments are available. While generally non-irritating, there is a noted likelihood of irritation, with risk potentially increasing when formulated alongside other problematic ingredients. Aesthetic and stability issues may also limit its usefulness.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Insufficient Data

While demonstrating promising antioxidant and neuroprotective properties in *in vitro* neuronal models, a lack of direct human skin efficacy studies and formal safety assessments indicates insufficient data for confident recommendation in topical formulations.


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