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Moumoujus

SEDUM ACRE EXTRACT.

Valuable CAS 90106-69-7 / SKIN CONDITIONING

Sedum Acre Extract is a botanical active renowned for its multifaceted benefits, including potent antioxidant action, soothing properties, and enhancement of the skin's natural barrier. It aids in moisture retention and supports overall skin regeneration, contributing to a more resilient and balanced complexion.

Summary

Skin conditioning Antioxidant Anti-inflammatory Soothing Moisturizing Barrier strengthening Regenerative support Wound healing support

Science

Mechanism of Action

This extract functions as a powerful antioxidant primarily due to its rich phenolic content. It supports skin comfort by promoting the release of relaxing beta-endorphins within sensory neurons, which effectively mitigates irritation and redness. The extract fortifies the skin's protective barrier, diminishing sensitivity to environmental stressors and internal triggers, while also sustaining skin moisture through the swelling capacity of its long-chain sugars. It delivers a sustained anti-inflammatory response that can assist in managing acne and supporting scar healing. Furthermore, Sedum Acre Extract stimulates fibroblast proliferation, crucial for skin repair, and contributes to regeneration through bioactive flavonols and polysaccharides with anti-inflammatory and immunomodulatory properties.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Various Sedum acre extracts (methanol, acetone, ethyl acetate) demonstrated antioxidant activity with IC50 values for DPPH scavenging ranging from 29.57 to 987.16 μg/mL. The acetone extract exhibited the highest phenolic content and DPPH radical neutralizing capacity.
  2. 02 A methanol extract of Sedum acre exhibited medium antiproliferative activity on the HCT-116 cell line, with IC50 values of 281.69 μg/mL at 24 hours and 126.57 μg/mL at 72 hours.
  3. 03 May-harvested extracts of Sedum acre were observed to stimulate fibroblast proliferation, indicating potential for wound healing support.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

The presence of long-chain sugars in aqueous Sedum Acre extracts enables them to swell, underscoring their water solubility and contributing to their moisturizing properties. Extracts are typically prepared using solvents such as water, ethyl alcohol, glycerine, glycols, or vegetable oil. Specific optimal pH ranges for the stability of Sedum Acre Extract within cosmetic formulations are not extensively documented in available research.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Sedum Acre Extract has not undergone specific review by the Cosmetic Ingredient Review (CIR) Expert Panel, nor has a safety opinion from the SCCS been identified. Under U.S. law, cosmetic ingredients, excluding color additives, do not require FDA approval prior to marketing. It is important to note that the raw Sedum acre plant's leaves contain an acrid fluid that historically has been associated with skin rashes and vesication upon topical application. However, data regarding skin allergies and irritation for the cosmetic extract are classified as 'No Data' by the EWG.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Sedum Acre Extract is a valuable botanical ingredient, offering multifaceted benefits including antioxidant protection, anti-inflammatory effects, barrier strengthening, and support for skin regeneration, making it suitable for a wide range of skin concerns.

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