Science
Mechanism of Action
This ingredient operates via a sophisticated interplay of bioactive compounds, including phenolics, carotenoids, flavonoids, alkaloids, and saponins. These constituents confer significant antioxidant activity, effectively neutralizing reactive oxygen species and mitigating oxidative stress. It shields keratinocytes from UVA-induced cytotoxicity, demonstrating anti-inflammatory and genoprotective properties. Furthermore, it acts as a skin conditioning agent, promoting softness and smoothness, and has shown promise in reducing Matrix Metalloproteinase-2 (MMP-2) levels and boosting collagen density to support skin regeneration.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Protected keratinocytes against UVA-induced cytotoxicity and significantly decreased intracellular reactive oxygen species.
- 02 Demonstrated the capacity to moisturize skin by up to 20% and effectively remove oxygen free radicals, supporting anti-aging benefits.
- 03 Reduced Matrix Metalloproteinase-2 (MMP-2) levels and increased collagen density, indicating potential support for wound healing processes.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
A gel formulation containing chayote peel extract exhibited physical stability over 30 days at 4 °C and 25 °C within a pH range of 5.61 ± 0.32. Chayote fruit juice typically has a pH between 6.0 and 6.8. Components like Vitamin C, naturally present in chayote, are prone to degradation when exposed to light, elevated temperatures, or increased pH. Introducing ingredients like pineapple juice can significantly lower the overall pH of formulations containing chayote juice.
Conflicts
- Rapid degradation of Vitamin C and other susceptible bioactive compounds when exposed to light, heat, or pH values outside the optimal range (5.5-6.8).
Safety
Safety Profile
Chayote peel extracts demonstrated low cytotoxicity in keratinocyte (HaCaT) cells at concentrations up to 100 μg/mL; however, cell viability decreased by approximately 54% at 1000 μg/mL. An extract from *Sechium edule* var. *nigrum spinosum* recorded an LD50 exceeding 5000 mg/kg, indicating a high safety margin. In-vivo studies on ingested chayote fruit juice have shown no toxic effects or induction of micronuclei, further supporting its safety profile.
Your Skin
Skin Compatibility
Our Assessment
Verdict
SECHIUM EDULE FRUIT JUICE is a valuable ingredient, offering significant antioxidant, moisturizing, and protective benefits for a wide range of skin types, with a favorable safety profile.
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References
Sources