SEA WATER/ARTEMISIA ARGYI LEAF FERMENT EXTRACT.

This advanced ferment extract works through multiple pathways to enhance skin vitality. Its Artemisia argyi component exhibits potent bactericidal and anti-inflammatory properties, effectively reducing acne and alleviating irritation. For hydration, it influences critical factors like AQP3 and HAS2, contributing to moisturized skin. The extract provides significant antioxidant defense by effectively scavenging DPPH free radicals and upregulating vital antioxidant enzymes such as GPX1 and SOD1, with compounds like quercetin and luteolin neutralizing free radicals to prevent photoaging. Its intense soothing and anti-redness capabilities stem from compounds such as chamazulene and jaceosidin, which inhibit inflammatory mediator release from macrophages and reduce inflammatory cytokine production (e.g., IFN-γ, TNF-α, IL-6), as well as suppress COX-2 and iNOS expression, and NO and PGE2 production. Furthermore, it aids in skin barrier restoration by stimulating ceramide production, thereby enhancing lipid bilayer integrity and reducing transepidermal water loss. The fermentation process with lactic acid bacteria significantly elevates the levels of beneficial flavonoids and polyphenols in Artemisia argyi leaves, amplifying these complex bio-activities. Mild cellular turnover and brightening effects may also be attributed to natural salicylic acid derivatives.