Science
Mechanism of Action
This extract primarily exerts its anti-inflammatory effects by suppressing the phosphorylation of NF-κB and concurrently enhancing the Nrf2/HO-1 signaling pathway, which are critical cellular mechanisms for mitigating inflammation and oxidative stress. Its inherent antioxidant properties further contribute to cellular protection. The active components, including iridoids and phenylpropanoids, are believed to be central to these anti-inflammatory actions. Additionally, it functions as a humectant, attracting and retaining moisture within the skin, and serves as a general skin conditioning agent.
Research
Clinical Evidence
Low confidenceN/A
Key findings
- 01 Significantly reduced proinflammatory cytokines, inflammatory cell counts, immunoglobulin-E, and airway hyperresponsiveness; decreased airway inflammation and mucus production.
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
SCROPHULARIA KORAIENSIS ROOT EXTRACT is currently under active review by the Cosmetic Ingredient Review (CIR) Expert Panel. It has been placed on the 'ADMIN Priorities' list as of September 11, 2023, for evaluation as a 'Skin-Conditioning Agent – Miscellaneous' and 'Antioxidant'. This indicates that a comprehensive safety assessment for cosmetic applications is ongoing, and a final, published safety determination has not yet been issued.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While SCROPHULARIA KORAIENSIS ROOT EXTRACT demonstrates promising anti-inflammatory and antioxidant properties in preclinical animal models, its safety and efficacy for human topical applications are presently under formal review by the CIR, indicating that further data is required for a conclusive recommendation.
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References
Sources