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Moumoujus

SCOPARIA DULCIS EXTRACT.

Valuable CAS - / SKIN CONDITIONING

Scoparia Dulcis Extract is a botanical ingredient recognized for its multifaceted benefits, primarily its anti-inflammatory, antioxidant, and wound-healing properties. It works to soothe skin, protect against oxidative damage, and support barrier repair, making it valuable for diverse skin concerns.

Summary

Anti-inflammatory Antioxidant Antimicrobial Wound Healing Skin Soothing

Science

Mechanism of Action

Scoparia Dulcis Extract exerts anti-inflammatory actions by influencing cytokine levels, specifically reducing IFN-γ and IL-6 while potentially increasing IL-10, and also functions as a COX inhibitor. Its antioxidant efficacy stems from reducing reactive oxygen species (ROS) and preventing the depletion of crucial antioxidative enzymes such as superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GRd), and glutathione-S-transferase (GST), alongside enhancing catalase expression. The presence of beneficial compounds including flavonoids, terpenoids, and alkaloids further contributes to its anti-inflammatory, antimicrobial, and antioxidant activities, supporting its demonstrated wound healing capabilities.

Research

Clinical Evidence

Medium confidence
Effective range 25–200%
Optimal

N/A

Key findings

  1. 01 In in vitro cyclooxygenase inhibition assays, 50 µg/mL of the extract inhibited COX-1 activity by up to 11.69% and COX-2 by 12.57%.
  2. 02 In human retinal pigment epithelial cells exposed to high glucose, concentrations from 25 to 200 μg/mL dose-dependently enhanced catalase expression, indicating significant anti-oxidative effects.
  3. 03 Hymenoxin, a compound isolated from Scoparia dulcis, was shown to inhibit oxidative stress by 16% at a concentration of 125 μg/mL.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Acute toxicity studies in rats showed the ethanolic extract to be practically nontoxic at high doses, with an LD50 of 2738.61 mg/kg. Traditional uses suggest contraindications during pregnancy and for individuals with hypoglycemia, and caution with certain medications, though these primarily relate to internal consumption and traditional medicinal uses rather than topical cosmetic applications. Further data on topical pregnancy safety is not available.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Scoparia Dulcis Extract offers valuable anti-inflammatory, antioxidant, and wound-healing benefits, making it a versatile ingredient for soothing and protecting various skin types.

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