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Moumoujus

SCLAREOLIDE.

Valuable CAS 564-20-5 / FRAGRANCE, PERFUMING, SKIN CONDITIONING

Sclareolide is a multifunctional ingredient derived from clary sage, recognized for its precision in addressing various skin and scalp concerns. It offers significant skin brightening, anti-aging, and moisturizing benefits, while also effectively combating scalp inflammation and microbial imbalance.

Summary

Antioxidant Anti-inflammatory Anti-bacterial Skin Brightening Skin Conditioning Anti-photoaging Anti-dandruff Perfuming Masking

Science

Mechanism of Action

Sclareolide acts through multiple pathways: it delivers antioxidant and anti-inflammatory protection against environmental stressors, exhibits anti-bacterial properties to help prevent acne, and significantly inhibits UV-induced melanin production for a brighter complexion. In scalp care, it reduces inflammation and helps normalize the microbial environment to alleviate dandruff. Furthermore, it functions as a skin conditioning agent by forming a protective, moisture-trapping layer, stimulating epidermal lipid production to strengthen the skin barrier, and preventing collagen degradation by inhibiting UV-B induced MMPs and down-regulating AP-1 transcription factors.

Research

Clinical Evidence

Medium confidence
Effective range 0.1–0.5%
Optimal

N/A

Key findings

  1. 01 Demonstrated inhibition of UV-induced pigmentation and melanin production, leading to measurable skin brightening in facial serums, creams, and sun care products.
  2. 02 Proven to reduce scalp inflammation and control microbial imbalance when used in leave-on scalp treatments for anti-dandruff efficacy.
  3. 03 Shown to reduce scalp inflammation and regulate microbial balance in rinse-off anti-dandruff shampoos.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Sclareolide exhibits robust stability against degradation from heat, light, and air. It is sparingly soluble in aqueous buffers (less than 1 mg/mL) but highly soluble in common organic solvents like ethanol, acetone, toluene, and isopropyl myristate, making it ideal for emulsion and oil-based systems. Aqueous solutions are not recommended for prolonged storage.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Generally considered safe for topical application. While some individuals may experience skin irritation or allergic reactions due to its volatile fragrance compounds, the Research Institute for Fragrance Materials (RIFM) found no concern for genotoxicity or skin sensitization in its assessment for fragrance use. It is also recognized as safe for specific food uses by the FDA (FEMA No. 3794, GRAS No. 16).

Your Skin

Skin Compatibility

No Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Sclareolide is a valuable ingredient for advanced skincare and scalp treatments, offering proven benefits in skin brightening, anti-aging, barrier support, and anti-dandruff efficacy at precise concentrations.

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