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Moumoujus

SCLAREOL.

Valuable CAS 515-03-7 / PERFUMING

Sclareol is a naturally occurring diterpene alcohol, primarily found in plants like Salvia officinalis. This ingredient demonstrates significant antiphotoaging and anti-inflammatory properties, making it highly relevant for targeted skincare formulations addressing signs of aging and environmental damage.

Summary

Anti-aging Anti-inflammatory Photoprotective Wrinkle Reduction Cellular Regeneration

Science

Mechanism of Action

Sclareol exerts its benefits through a multifaceted mechanism. It actively enhances cellular proliferation and effectively blocks UVB-induced cell death. It inhibits the expression of matrix metalloproteinases (MMPs), which are detrimental to skin structure, by regulating AP-1 transcription factors. Additionally, Sclareol possesses potent anti-inflammatory effects, attenuating inflammatory severity by inhibiting NF-κB translocation, reducing phosphorylation of MAPK signaling, decreasing local pro-inflammatory cytokine concentrations, and suppressing T-cell activation and cytokine production. These combined actions support recovery from UVB-induced damage and improve epidermal thickness.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

0.02%

Key findings

  1. 01 A clinical study at 0.02% concentration demonstrated significant improvement in facial wrinkles. Findings included enhanced cellular proliferation, blocked UVB-induced cell death, inhibition of UVB-induced mRNA expression of matrix metalloproteinases (MMPs) through AP-1 regulation, and recovery of UVB-induced decreases in epidermal thickness and PCNA expression, confirming robust antiphotoaging effects.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

Sclareol is generally considered non-toxic when used appropriately, with PubChem noting it does not meet GHS hazard criteria for 99.2% of reports. However, it is classified as a fragrance allergen, necessitating reporting if concentrations exceed 0.001% (10 ppm) in leave-on cosmetic products or 0.01% (100 ppm) in rinse-off products, according to the California Safe Cosmetics Program. While recommended usage levels within Salvia Sclarea Oil can range from 1-10%, there is no specific maximum concentration defined as a general safety limit for isolated Sclareol in cosmetics beyond these allergen thresholds. It has not been reviewed by the Cosmetic Ingredient Review (CIR).

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

With compelling clinical evidence at a 0.02% concentration for wrinkle improvement and a comprehensive antiphotoaging and anti-inflammatory mechanism, Sclareol is a valuable active ingredient for precision anti-aging and skin protection formulations.

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