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Moumoujus

SCHIZOPHYLLUM COMMUNE MYCELIUM.

Valuable / SKIN CONDITIONING - EMOLLIENT, SKIN CONDITIONING - HUMECTANT, SKIN CONDITIONING - MISCELLANEOUS

Schizophyllum Commune Mycelium is a fungal extract renowned for its multi-functional benefits in skincare. It acts as a potent antioxidant, actively scavenging free radicals to protect the skin from oxidative stress, while also promoting optimal skin hydration and barrier function. Furthermore, its demonstrated wound healing and anti-pigmentation properties contribute to a healthier, more even-toned complexion.

Summary

Antioxidant Humectant Skin-Conditioning Wound healing Antimicrobial Anti-inflammatory Brightening Immunomodulatory

Science

Mechanism of Action

This ingredient functions as a comprehensive skin conditioning agent, providing emollient and humectant benefits that soften, smooth, and lock in moisture. Its notable antioxidant activity involves scavenging free radicals, thereby mitigating oxidative stress. It also actively supports skin repair by stimulating re-epithelialization and dermal contraction through the activation of key pathways like Integrin/FAK/Src in the epidermis and dermal transformation via NOX4 expression. Additional benefits include immunomodulatory, anti-pigmentation (tyrosinase inhibition), and antibacterial actions.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Demonstrated 92.59% antioxidant activity via DPPH scavenging at a concentration of 16 mg/ml.
  2. 02 Exhibited 91.85% antioxidant scavenging ability at a concentration of 8.0 mg/mL.
  3. 03 Showed moderate Singlet Oxygen Absorption (SOA) scavenging activity, ranging between 40% to 58%, at an unspecified concentration.
  4. 04 Proven effective in stimulating wound healing by promoting re-epithelialization and dermal contraction, involving activation of Integrin/FAK/Src in the epidermis and dermal transformation via NOX4 expression and integrin upregulation.

Transparency

Dusting Analysis

Not commonly dusted

The research indicates specific in vitro concentrations yielding significant biological activity, suggesting it is not typically 'dusted' at sub-efficacious levels.

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 6.8
0 7 14

Stability

Optimal pH for preserving biological activity and mycelial growth is between 5.0 and 6.8, with some studies highlighting pH 5.0, 5.5, or 6.78 as specifically favorable. Aqueous extracts demonstrate enhanced antioxidant activity, indicating water-soluble bioactive compounds. Schizophyllan, a key polysaccharide, is water-soluble, forms viscous solutions, and possesses high thermal stability. Extreme pH conditions (highly acidic or basic) are likely detrimental to its activity.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

No specific cosmetic safety assessments by CIR, SCCS, or FDA were found. It is recognized in COSMILE Europe as a skin conditioning, emollient, and humectant agent. Generally regarded as non-toxic for consumption by healthy individuals. While rare opportunistic infections have been noted in severely immunocompromised individuals, this is not considered relevant for topical cosmetic application on healthy skin, suggesting a low risk of sensitization or adverse reactions for the general population.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Schizophyllum Commune Mycelium is a valuable, multi-beneficial ingredient offering strong antioxidant defense, significant wound healing capabilities, and excellent skin conditioning properties for diverse skin types.

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References

Sources