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Moumoujus

SCHIZANDRA SPHENANTHERA FRUIT EXTRACT.

Valuable CAS - / ANTI-SEBUM, ANTIOXIDANT, SKIN CONDITIONING, SKIN PROTECTING

Schizandra Sphenanthera Fruit Extract is a versatile botanical active, precisely targeting inflammatory pathways, oxidative stress, and hyperpigmentation. This multi-functional ingredient is particularly beneficial for fortifying compromised skin barriers and soothing hyper-reactive skin conditions.

Summary

Anti-inflammatory Antioxidant Soothing Moisturizing Skin Barrier Support Anti-aging Photoprotection Skin Brightening Collagen Protection

Science

Mechanism of Action

This extract operates through a multi-faceted approach to enhance skin health. It significantly reduces inflammation by inhibiting PGE2 production and suppressing COX-2 expression, key mediators in inflammatory responses. Its rich profile of lignans acts as powerful antioxidants, neutralizing free radicals and offering protection against environmental stressors and UVB radiation by potentially blocking inflammatory cytokines like IL-6 and IL-18. Schisandrin specifically enhances skin barrier integrity and mitigates inflammation, while Schizandrin B may regulate superoxide dismutase (SOD) activity and lower matrix metalloproteinase-1 (MMP-1) expression, thereby protecting collagen. Essential fatty acids and polysaccharides deliver vital hydration and reinforce the skin's lipid barrier, while vitamins C and E contribute to a brighter, more radiant complexion. Furthermore, it exerts an anti-melanogenesis effect through potent tyrosinase inhibition and stimulates endogenous antioxidant defenses by promoting glutathione production.

Research

Clinical Evidence

High confidence
Effective range 0.2–3%
Optimal

N/A

Key findings

  1. 01 At a concentration of 0.2 µg/mL, an SC-CO2 extract exhibited strong inhibition of prostaglandin production via cyclooxygenase-2 (COX-2) in a cell-free enzymatic assay.
  2. 02 UVB-induced PGE2 production and COX-2 expression in HaCaT keratinocytes were notably reduced by an SC-CO2 extract at 4 µg/mL.
  3. 03 A non-polar extract inhibited epidermal cell proliferation (HaCaT and A431 cells) with an IC50 of 20 µg/mL.
  4. 04 An aqueous extract, at 50 µg/mL, stimulated HaCaT cell proliferation, showing up to a 150% increase compared to controls.
  5. 05 Aqueous extracts demonstrated significant tyrosinase inhibition, ranging from 96.2% to 98.5%, at 50 µg/mL.
  6. 06 In a model body wash formulation, 3% (w/w) aqueous extract reduced skin irritant potential by up to 16%.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

The CO2-extracted oil form maintains stability for one year when stored in a sealed container, protected from light and kept in cool conditions.

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
3%
Sensitization risk Low

Formal safety reviews by CIR, SCCS, or FDA are not yet available. In vitro studies showed no cytotoxic effects on HaCaT cells at aqueous extract concentrations up to 200 µg/mL. Furthermore, model body wash gels containing 3% (w/w) of the aqueous extract demonstrated a reduction in skin irritant potential.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Schizandra Sphenanthera Fruit Extract is a multi-functional ingredient demonstrating significant anti-inflammatory, antioxidant, and brightening benefits, making it highly valuable for stressed, sensitive, and aging skin.

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