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Moumoujus

SCHINUS TEREBINTHIFOLIA LEAF EXTRACT.

Valuable / SKIN CONDITIONING

Schinus Terebinthifolia Leaf Extract, derived from the Brazilian peppertree, is a multi-functional botanical ingredient recognized for its potent antioxidant, anti-inflammatory, and antimicrobial properties. It offers a comprehensive approach to skin health, targeting oxidative stress, inflammatory responses, and microbial imbalances to promote a healthier skin environment.

Summary

Antioxidant Anti-inflammatory Antimicrobial Anti-allergic Skin conditioning

Science

Mechanism of Action

Schinus Terebinthifolia Leaf Extract exerts its beneficial effects through several precise mechanisms. Its antioxidant capacity stems from directly scavenging DPPH radicals, reducing lipid peroxidation, augmenting sulfhydryl content, and bolstering the activity of endogenous antioxidant enzymes such as catalase and superoxide dismutase. Anti-inflammatory actions are mediated by decreasing edema and myeloperoxidase activity, alongside a favorable modulation of cytokine profiles—reducing pro-inflammatory mediators (IL-6, TNF-α) while increasing anti-inflammatory ones (IL-10). Furthermore, it demonstrates anti-allergic properties by inhibiting edema formation and histamine release, potentially by influencing mast cell degranulation and eosinophil infiltration. The extract also exhibits broad-spectrum antimicrobial activity against both Gram-positive (e.g., Staphylococcus aureus) and Gram-negative (e.g., Escherichia coli, Pseudomonas aeruginosa) bacteria, through mechanisms including bacterial cell wall degradation, cell membrane disruption, inhibition of enzymatic functions, and prevention of biofilm formation.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In vitro antioxidant activity was demonstrated with an EC50 of 54.5 ± 2.4 µg/mL for DPPH radical scavenging and a reduction in lipoperoxidation at concentrations of 200–500 µg/mL. An ethanolic extract also achieved 92.8% DPPH inhibition at 200 mg/mL.
  2. 02 In vitro antibacterial activity was observed with a minimum inhibitory concentration (MIC) of 0.62 mg/mL against both Escherichia coli and Staphylococcus aureus.
  3. 03 Topical application in a TPA-induced ear inflammation model in mice significantly reduced edema and myeloperoxidase activity, confirming in vivo anti-inflammatory efficacy.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Supercritical CO2 extraction is noted to be beneficial for preserving the extract's natural chemical composition and enhancing its stability. Its complex profile of polar phenolic compounds and non-polar terpenes allows for solubility in both polar solvents, such as water and methanol, and non-polar solvents, like ethyl acetate, depending on the specific extract preparation.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

While acute oral toxicity studies in rats suggest a 75% ethanolic leaf extract is practically non-toxic up to a dose of 5 g/kg body weight/day, topical application has been associated with reported allergic reactions in some individuals. In vitro testing indicated no significant impact on fibroblast viability at concentrations up to 100 µg/mL.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Medium
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Schinus Terebinthifolia Leaf Extract is a valuable, multi-functional botanical offering significant antioxidant, anti-inflammatory, and antimicrobial benefits for skin conditioning, though further human clinical data and detailed safety assessments are recommended given its reported moderate sensitization risk.

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