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Moumoujus

SAURURUS CHINENSIS ROOT EXTRACT.

Valuable CAS - / BLEACHING

Saururus Chinensis Root Extract is a multi-functional botanical, scientifically recognized for its potent anti-inflammatory, antioxidant, and skin-brightening capabilities. It actively mitigates oxidative stress and calms inflammatory responses, while also addressing hyperpigmentation through melanin inhibition. This ingredient is suitable across all skin types, including sensitive.

Summary

Antioxidant Brightening Soothing Antimicrobial Detoxification Anti-inflammatory Astringent Emollient Skin conditioning Skin protecting

Science

Mechanism of Action

This extract operates through several key pathways to promote skin health. Its anti-inflammatory action involves significantly suppressing nitric oxide (NO) production in RAW 264.7 macrophages by inhibiting inducible NO synthase (iNOS) mRNA and NFkappaB activity. It also reduces tumor necrosis factor (TNF)-alpha synthesis by blocking c-Raf-MEK1/2-ERK1/2 phosphorylation and the TAK1/AP-1 pathway. As an antioxidant, it directly scavenges free radicals, including DPPH, H2O2, NO, and ABTS, while simultaneously enhancing the skin's natural antioxidative defense systems. For skin brightening, it inhibits melanin production, indirectly decreases α-MSH-induced tyrosinase activity, and reduces MITF and tyrosinase expression via extracellular signal-regulated kinase (ERK) activation. Additional benefits include balancing sebum production, providing moisturizing effects, and exhibiting antimicrobial and astringent properties, contributing to overall skin protection.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Saururus chinensis methanol extract (0-45 µg/mL) significantly reduced LPS-stimulated nitric oxide production, suppressed iNOS mRNA expression, and inhibited NFkappaB activity in RAW 264.7 macrophages, demonstrating potent anti-inflammatory effects.
  2. 02 Ethanol extract (25, 50, and 100 µg/mL) exhibited significant radical-scavenging activity against DPPH, H2O2, NO, and ABTS radicals, confirming its antioxidant capacity.
  3. 03 Saururi chinensis extracts demonstrated dose-dependent inhibition of melanin production in B16F10 cells without cytotoxicity. It decreased α-MSH-induced tyrosinase activity indirectly and reduced MITF and tyrosinase expression by activating extracellular signal-regulated kinase (ERK).

Transparency

Dusting Analysis

Not commonly dusted

The provided research data does not contain specific information regarding dusting practices or threshold percentages for Saururus Chinensis Root Extract.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

No specific stability notes are available in the provided data.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

Saururus Chinensis Root Extract is generally considered safe for cosmetic use and adheres to regulations in various countries. However, as a natural botanical ingredient, it carries a moderate risk of individual allergic reactions, which may manifest as skin irritation, redness, or itching, especially in individuals sensitive to plant extracts. A patch test is advisable prior to full application. The Cosmetic Ingredient Review (CIR) Expert Panel has not formally reviewed this ingredient.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Saururus Chinensis Root Extract is a valuable botanical ingredient, offering significant anti-inflammatory, antioxidant, and skin-brightening benefits that make it highly suitable for addressing a wide spectrum of skin concerns across all skin types.

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