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Moumoujus

SAURURUS CHINENSIS LEAF/STEM EXTRACT.

Valuable / SKIN CONDITIONING

Saururus Chinensis Leaf/Stem Extract is a botanical powerhouse, rich in flavonoids and polyphenols, delivering multifaceted benefits. It effectively calms inflammation, neutralizes oxidative stress, and helps regulate sebum production for balanced skin. Additionally, this extract contributes to a more even skin tone by addressing hyperpigmentation concerns.

Summary

Antioxidant Anti-inflammatory Soothing Skin brightening Sebum control Anti-aging Moisturizing

Science

Mechanism of Action

This extract acts as a potent antioxidant by scavenging free radicals and mitigating oxidative stress through its rich flavonoid and polyphenol content. Its anti-inflammatory action is achieved by reducing key inflammatory markers such as IL-6 and TNF-alpha, and by inhibiting signaling pathways like NF-κB and TAK1/AP-1. For skin brightening, it reduces melanin production via a non-enzymatic pathway, decreasing tyrosinase and MITF expression, and activating ERK. It also supports oil balance by regulating excess sebum, while its anti-aging properties involve preventing MMP-1 upregulation, reducing reactive oxygen species, and boosting glutathione levels to protect against photoaging.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Demonstrated significant, concentration-dependent inhibition of LPS-induced nitric oxide (NO), inducible NO synthase (iNOS), and cyclooxygenase-2 (COX-2) production in BV-2 microglial cells. It also suppressed inflammatory cytokines (TNF-α, IL-6) and NF-κB activation, alongside exhibiting antioxidant effects with IC50 values of 0.055 mg/mL for DPPH and 0.349 mg/mL for alkyl radicals.
  2. 02 Successfully inhibited melanin production in B16F10 melanoma cells without cytotoxicity. It reduced α-MSH-induced tyrosinase and MITF expression, while activating extracellular signal-regulated kinase (ERK).
  3. 03 In a type II collagen-induced arthritis mouse model, oral administration decreased serum levels of Interleukin-6 (IL-6), TNF-alpha, and collagen IgG, and visibly reduced hind limb swelling.

Transparency

Dusting Analysis

Not commonly dusted

Current research data does not indicate that Saururus Chinensis Leaf/Stem Extract is commonly used at ineffective 'dusting' concentrations.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

While a precise optimal pH range for stability in cosmetic formulations is not available, the extract has been successfully obtained using various polar (water, hydro-alcoholic) and some less polar (ethanol, ethyl acetate) solvents, indicating broad solubility characteristics. Compatibility testing within specific formulations is recommended.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Generally regarded as safe for cosmetic use, adhering to regulatory standards in many regions. However, as with all natural ingredients, individuals with known sensitivities to botanicals may experience allergic reactions such as irritation or redness. A preliminary patch test is advised for highly sensitive skin types.

Your Skin

Skin Compatibility

Yes Normal
No Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Saururus Chinensis Leaf/Stem Extract is a valuable multi-functional ingredient offering significant antioxidant, anti-inflammatory, and skin brightening benefits for various skin types and concerns.

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