Science
Mechanism of Action
This extract operates through a multifaceted approach, largely attributed to active compounds such as tricin, p-coumaric acid, and ferulic acid. It enhances skin moisturization and wound repair by notably increasing the expression of aquaporin-3 (AQP3), a critical channel for water and glycerol transport in keratinocytes, potentially via p38 MAPK signaling activation. Furthermore, it exhibits potent antioxidant capabilities by mitigating oxidative stress, possesses anti-inflammatory effects, and offers cellular protection against various stressors.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 At concentrations from 0.003% to 0.03%, it protected human embryonic palatal mesenchymal cells from all-trans-retinoic acid-induced inhibition of proliferation and toxicity.
- 02 A 1% concentration demonstrated wound-healing and skin-moisturizing effects in a mouse model, significantly reducing wound area and increasing dermal water content.
- 03 At 0.05% (500 µg/mL) and 0.1% (1000 µg/mL), it increased mRNA and protein expression of aquaporin-3 (AQP3) in human epidermal keratinocytes (HaCaT cells) after 72 hours.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The extraction process involves boiling in 15% sodium hydroxide solution and subsequent pH adjustment to 7, suggesting broad pH stability during manufacturing. However, specific optimal pH ranges for final product stability have not been precisely determined.
Safety
Safety Profile
While formal Cosmetic Ingredient Review (CIR) or SCCS assessments are not available, external toxicology databases indicate low concerns regarding potential for cancer, allergies & immunotoxicity, and developmental & reproductive toxicity.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Sasa Veitchii Leaf Extract is a valuable botanical ingredient, offering significant moisturization, wound-healing, and protective benefits suitable for diverse skin types with low reported safety concerns.
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