Science
Mechanism of Action
This ingredient functions by increasing the expression of aquaporin-3 (AQP3) in skin cells. AQP3 is a transmembrane protein vital for facilitating the movement of water and glycerol, thereby contributing to enhanced dermal water content and supporting the wound-healing process. The upregulation of AQP3 is potentially mediated through the activation of the p38 mitogen-activated protein kinase (MAPK) signaling pathway.
Research
Clinical Evidence
Medium confidence0.1%
Key findings
- 01 In HaCaT cells, Sasa Veitchii extract significantly increased AQP3 mRNA expression in a concentration-dependent manner, with effects observed from 0.05% (500 μg/mL).
- 02 Treatment with 0.1% Sasa Veitchii extract in HaCaT cells led to increased AQP3 protein expression after 72 hours and phosphorylation of p38 MAPK after 1 hour.
- 03 Topical application in a mouse wound model for 14 days resulted in reduced wound areas and significantly elevated dermal water content compared to control groups.
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
No specific safety assessments from regulatory bodies such as CIR, SCCS, or FDA are currently available for Sasa Veitchii extract.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Sasa Veitchii is a promising botanical ingredient for enhancing skin hydration and supporting skin repair, primarily through AQP3 upregulation, though further human clinical and safety evaluations are warranted.
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References
Sources