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Moumoujus

SARGASSUM GLAUCESCENS EXTRACT.

Valuable / ANTIOXIDANT

This marine extract offers a multitude of benefits for skin health, functioning as a potent antioxidant, stimulating cellular regeneration, and fortifying the skin's natural barrier. It provides comprehensive protection against environmental stressors while enhancing moisture retention and promoting overall skin vitality.

Summary

Antioxidant Skin protecting Moisturizing Anti-inflammatory Skin conditioning Humectant Cell regenerating Skin barrier repair Antibacterial Anti-aging Hypopigmented

Science

Mechanism of Action

Sargassum glaucescens extract acts as a powerful antioxidant by directly scavenging free radicals and suppressing H2O2-induced reactive oxygen species (ROS) production. It stimulates cell renewal and protects dermal cells from UVA irradiation through the upregulation of key anti-oxidative genes (SOD1, GPX1) and DNA repair regulatory genes (XRCC1, ERCC6). Furthermore, it promotes the proliferation of human primary epidermal keratinocytes and reinforces the skin barrier by inducing the expression of genes such as TGM1, KRT10, and KRT14. Its hygroscopic nature helps maintain skin smoothness and suppleness, further supported by its ability to boost Natural Moisturizing Factor (NMF) production via Filaggrin (FLG) gene induction. The extract also exhibits anti-inflammatory, hypopigmenting, anti-wrinkle, and antibacterial properties.

Research

Clinical Evidence

Medium confidence
Effective range 0.03125 mg/ml–3 mg/ml (in scaffold)%
Optimal

N/A

Key findings

  1. 01 At 2 mg/ml, it stimulated the wound closure of CCD-966SK fibroblasts by 2.95-fold.
  2. 02 Concentrations between 0.25 and 1 mg/ml promoted CCD-966SK cell regeneration following UVA irradiation.
  3. 03 At 1 mg/ml, it induced expressions of anti-oxidative genes (SOD1, GPX1) and DNA repair regulatory genes (XRCC1, ERCC6) in UVA-irradiated CCD-966SK cells.
  4. 04 A concentration of 0.03125 mg/ml induced expressions of skin barrier-related genes (TGM1, KRT10, KRT14) and the NMF-promoting FLG gene in human primary epidermal keratinocytes.
  5. 05 It blocked H2O2-induced intracellular reactive oxygen species (ROS) generation by 77% at 0.125 mg/ml and reduced levels by 60% at 0.25 mg/ml.
  6. 06 It achieved 92.8% DPPH scavenging activity at 10 mg/ml.
  7. 07 When incorporated into collagen scaffolds, concentrations of 1-3 mg/ml demonstrated excellent antioxidant and antibacterial activity, improved structural stability, and enhanced cell proliferation without cytotoxicity, with 3 mg/ml exhibiting the highest cellular activity.

Transparency

Dusting Analysis

Not commonly dusted

Current research data does not suggest this ingredient is commonly used at sub-efficacious concentrations for marketing claims.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Extracts can be obtained via hot-water methods. The composition may exhibit seasonal variation. It has been successfully incorporated into collagen scaffolds and tested effectively at pH 7.4.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

A specific Cosmetic Ingredient Review (CIR) assessment for Sargassum glaucescens extract is not available. However, the CIR has reviewed a general category of 'Brown Algae-Derived Ingredients', finding most to be safe. Studies on Sargassum glaucescens extract specifically indicate no toxic effects and show an enhancement of cell proliferation without cytotoxicity, suggesting a favorable safety profile.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Sargassum glaucescens extract is a valuable marine ingredient offering potent antioxidant protection, comprehensive skin barrier support, and cellular regeneration benefits suitable for diverse skin types.

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