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Moumoujus

SARGACHROMANOL E.

Insufficient Data CAS - / SKIN CONDITIONING

Sargachromanol E is a chromene derived from brown algae, notably *Sargassum horneri* and *Sargassum serratifolium*. It exhibits potent antioxidant, anti-inflammatory, and anti-aging properties, primarily by mitigating ultraviolet A (UVA)-induced skin damage and oxidative stress.

Summary

Antioxidant Anti-aging Anti-inflammatory Photoprotective

Science

Mechanism of Action

Sargachromanol E operates on multiple biological pathways to support skin health. As a potent antioxidant, it effectively neutralizes reactive oxygen species (ROS) and prevents membrane protein and lipid oxidation, thereby protecting against UVA-induced cellular damage. Its anti-aging efficacy stems from inhibiting key collagen-degrading enzymes (MMP-1, MMP-2, MMP-9) and simultaneously upregulating tissue inhibitors of metalloproteinases (TIMP1, TIMP2), crucial for preserving extracellular matrix integrity. Furthermore, it exerts anti-inflammatory effects by reducing nitric oxide (NO) production, modulating pro-inflammatory cytokines (TNF-α, IL-1β, IL-6), and inhibiting inflammatory mediators and signaling pathways like NFκB and MAPK, which are central to inflammatory responses.

Research

Clinical Evidence

Medium confidence
Effective range 0.00078–0.05%
Optimal

N/A

Key findings

  1. 01 Inhibitory effect on inflammatory responses, including nitric oxide production, in LPS-stimulated RAW 264.7 macrophages at concentrations ranging from 0.00078% to 0.00625%, demonstrating efficacy without significant cytotoxicity.
  2. 02 An ethanolic extract containing sargachromanol, applied at concentrations of 0.01% to 0.05% (100-500 ppm), improved skin condition in a DNCB-induced mouse model of atopic dermatitis.
  3. 03 Inhibited ultraviolet A (UVA)-induced skin aging in human dermal fibroblasts by suppressing intracellular reactive oxygen species (ROS) formation, membrane protein oxidation, lipid peroxidation, and the expression of collagenases (MMP-1, -2, -9). It also increased the expression of tissue inhibitor of metalloproteinase (TIMP) genes (TIMP1, TIMP2).

Transparency

Dusting Analysis

Not commonly dusted

Sargachromanol E demonstrates significant biological activity at very low concentrations, with documented effects observed as low as 0.00078%. While this suggests efficacy is achievable without high inclusion rates, there is no specific data indicating it is commonly 'dusted' or used deceptively at ineffective trace amounts in formulations.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Unknown

Safety assessments of brown algae-derived ingredients, which include Sargachromanol E, have noted insufficient specific data to definitively conclude its safety 'as used' in cosmetic formulations. While many broader brown algae extracts are considered safe, specific comprehensive toxicological and clinical safety data for Sargachromanol E itself are lacking.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

Sargachromanol E presents compelling preliminary evidence for antioxidant, anti-aging, and anti-inflammatory benefits across several studies, yet its overall safety profile remains undetermined due to insufficient specific data for cosmetic use.

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