Science
Mechanism of Action
Santolina chamaecyparissus extract functions through the synergistic action of its rich phytochemical profile, encompassing phenolic compounds, flavonoids, and terpenes. These compounds confer its anti-inflammatory effects, effectively reducing skin redness and swelling. Its antimicrobial activity extends to common skin pathogens such as Propionibacterium acnes, along with P. aeruginosa, S. aureus, E. coli, C. albicans, and A. brasiliensis, making it a potent purifying agent. Additionally, its antioxidant constituents work to protect skin cells from oxidative stress.
Research
Clinical Evidence
Medium confidence0.4%
Key findings
- 01 Demonstrated robust antimicrobial activity against five common microorganisms (P. aeruginosa, S. aureus, E. coli, C. albicans, A. brasiliensis) when incorporated into cosmetic preparations, exhibiting superior inhibition compared to the crude extract alone.
- 02 Topical application of a crude extract at 100 mg/kg significantly reduced Phorbol-12-myristate-13-acetate (PMA)-induced mouse ear oedema, surpassing the anti-inflammatory efficacy of diclofenac at 10 mg/kg.
Transparency
Dusting Analysis
No data available to suggest 'dusting' or under-dosing is a common issue with this ingredient.
The Formula
Formulation
Stability
Isolated pure compounds derived from Santolina chamaecyparissus may exhibit instability, especially under aqueous and acidic conditions, which warrants careful formulation considerations.
Conflicts
- Acidic conditions (for the pure compound)
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) and European Scientific Committee on Consumer Safety (SCCS) have not formally reviewed Santolina chamaecyparissus extract for general cosmetic use. It is noted that this ingredient is prohibited for use as a fragrance ingredient, suggesting potential considerations for sensitive individuals, although direct sensitization data for the extract in skincare is unknown. FDA status for cosmetic use is not specifically reviewed.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Santolina Chamaecyparissus Extract is a valuable botanical ingredient, demonstrating potent antimicrobial and anti-inflammatory benefits particularly for oily and sensitive skin types, although comprehensive regulatory safety assessments are currently outstanding.
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References
Sources