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Moumoujus

SANGUISORBA OFFICINALIS ROOT EXTRACT.

Valuable CAS 84787-71-3 / CLEANSING, REFRESHING, SKIN CONDITIONING, TONIC

Sanguisorba Officinalis Root Extract, derived from the Great Burnet plant, is a multifaceted botanical ingredient celebrated for its ability to enhance skin elasticity, reduce the appearance of wrinkles, and significantly improve hair growth while mitigating hair loss. It further offers protective benefits through its antioxidant, anti-inflammatory, and antimicrobial properties.

Summary

Hair Growth Promoter Anti-Hair Loss Anti-Aging Skin Elasticity Enhancer Antioxidant Soothing Anti-Acne Antimicrobial Skin Conditioner

Science

Mechanism of Action

This extract precisely targets key biological pathways to deliver its benefits. In the skin, it inhibits HYBID (KIAA1199)-mediated hyaluronan degradation and down-regulates HYBID mRNA and protein expression within fibroblasts, promoting the production of high-molecular-weight hyaluronic acid for improved skin elasticity and reduced wrinkles. For hair, it functions as an FGF-5 inhibitor, effectively prolonging the anagen phase of hair growth by preventing follicles from prematurely transitioning to the catagen phase. Additionally, its inherent antioxidant, anti-inflammatory, and antimicrobial characteristics contribute to overall skin and scalp health.

Research

Clinical Evidence

Medium confidence
Effective range ≥10%
Optimal

10%

Key findings

  1. 01 A 10% topical solution demonstrated significant efficacy over time, reducing hair loss by 13.3% within 2 months and 32% after 4 months. Concurrently, hair growth increased by 11.9% in 2 months and 17.7% in 4 months in a study involving 39 subjects.
  2. 02 A lotion containing Sanguisorba officinalis root extract led to a significant improvement in skin elasticity and a reduction in skin wrinkling scores at the outer eye corner. This was observed in a double-blind, randomized, placebo-controlled study involving 21 healthy Japanese women, though the specific extract concentration in the final formulation was not detailed.
  3. 03 Ethanolic extracts, prepared with dry extract content ranging from 50-500 g/L, exhibited high antioxidant activity comparable across 40% and 70% aqueous ethanol solutions due to their polyphenol content. These extracts also showed antibacterial activity against various Gram-positive and Gram-negative strains, with the highest inhibition zones observed at 500 g/L dry extract concentration.

Transparency

Dusting Analysis

Not commonly dusted

No data available to suggest Sanguisorba Officinalis Root Extract is commonly used at ineffective concentrations or as a 'dusted' ingredient in formulations.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

The extract is stable in hydroalcoholic systems, commonly prepared using aqueous ethanol solutions (e.g., 40% and 70%). Its antioxidant potential, attributed to phenolic compounds, contributes to its stability.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

While listed as a cosmetic agent and subject to general cosmetic ingredient regulations, specific safety assessments by CIR, SCCS, or FDA for cosmetic use were not found in the provided research. Given its low irritancy profile, it is generally considered well-tolerated.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Sanguisorba Officinalis Root Extract is a valuable ingredient, demonstrating robust clinical efficacy in promoting hair growth, reducing hair loss, improving skin elasticity, and diminishing wrinkles, further supported by its antioxidant, soothing, and antimicrobial properties.

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