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SALVIA SCLAREA FLOWER/LEAF/STEM EXTRACT.

Valuable CAS 84775-83-7 / SKIN CONDITIONING

Salvia Sclarea Flower/Leaf/Stem Extract, derived from Clary Sage, is a multifunctional botanical ingredient known for its comprehensive skincare benefits. It acts as a potent antioxidant, safeguards against environmental damage, and actively addresses various skin concerns through its anti-inflammatory, sebum-regulating, and regenerative properties.

Summary

Skin conditioning Antioxidant Anti-inflammatory Sebum-regulating Antimicrobial Skin regenerating Moisturizing

Science

Mechanism of Action

This extract operates through multiple pathways to enhance skin health. Its antioxidant capacity stems from bioactive compounds like flavonoids and terpenes, which neutralize free radicals to prevent cellular damage and mitigate signs of aging. It exerts anti-inflammatory effects by moderating inflammatory markers, thereby soothing sensitive or irritated skin and potentially benefiting conditions such as acne, eczema, and rosacea. Furthermore, Salvia Sclarea extract possesses antimicrobial and antibacterial properties, helping to combat skin infections, specifically targeting bacteria implicated in acne like Staphylococcus aureus and S. epidermidis, and supporting wound healing by reducing microbial colonization. It helps normalize sebum production, making it valuable for oily or combination skin by reducing shine and preventing breakouts. The extract also contributes to skin regeneration, improving microcirculation, and potentially stimulating the synthesis of collagen and elastin, essential proteins for tissue repair and elasticity. It provides hydration without contributing to pore occlusion.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 An in-vitro study demonstrated higher antioxidant activity (DPPH IC50) for a maceration extract at 260.70 ± 65.41 mg/mL.
  2. 02 In-vitro DPPH radical scavenging activity (IC50) for a methanolic extract was reported at 58.20 μg/mL.
  3. 03 Non-polar subfractions of methanol extracts exhibited in-vitro DPPH radical scavenging activity (IC50) at 23.4 mg/mL.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH 4.5 – 6
0 7 14

Stability

No specific stability notes provided.

Conflicts

  • Direct application to skin without appropriate dilution is not recommended.
  • Use by pregnant women due to potential estrogen-like action.
  • Use by breastfeeding women due to potential estrogen-like action.
  • Use by children due to potential estrogen-like action.
  • Use by individuals with hormone-dependent pathologies due to potential estrogen-like action.

Safety

Safety Profile

CIR Status
Not reviewed
Pregnancy
Caution
Sensitization risk Low

Salvia Sclarea Extract is generally considered safe for topical cosmetic use at recommended concentrations, exhibiting a low potential for irritation and suitability for most skin types. However, given its complex composition, including components that might derive from clary sage essential oil, patch testing is advised, particularly for individuals with sensitive skin. Notably, clary sage essential oil, and by extension its extract components, may possess an estrogen-like action. This necessitates a contraindication for use in pregnant or breastfeeding women, children, and individuals with hormone-dependent pathologies. The FDA does not regulate essential oils.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Salvia Sclarea Flower/Leaf/Stem Extract offers a valuable array of antioxidant, anti-inflammatory, and balancing benefits for diverse skin types, though clinical efficacy on human skin for all mechanisms requires further in-vivo investigation beyond current in-vitro antioxidant studies.

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