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Moumoujus

SALVIA OFFICINALIS LEAF OIL.

Valuable CAS 8022-56-8 (generic), 84776-73-8 (generic) / PROPELLANT

Derived from the common sage plant, Salvia Officinalis Leaf Oil is a potent botanical extract recognized for its significant antioxidant, anti-inflammatory, and antimicrobial benefits. It supports comprehensive skin health by protecting against environmental stressors, soothing irritation, and purifying the skin.

Summary

Antioxidant Anti-inflammatory Antimicrobial Antibacterial Antifungal Astringent Perfuming

Science

Mechanism of Action

This essential oil exerts its antioxidant effects by actively scavenging free radicals, primarily through constituents like thujone and camphor, thereby mitigating oxidative stress and premature aging. Its anti-inflammatory action, partly attributed to inhibiting nitric oxide (NO) production, helps to reduce redness, swelling, and discomfort, making it beneficial for conditions such as acne and eczema. Furthermore, it offers robust antimicrobial, antibacterial, and antifungal properties that combat various pathogens, assist in managing acne, and promote skin healing. The oil also functions as an astringent, gently tightening pores and regulating sebum production, while simultaneously nourishing the skin to enhance elasticity and support cell turnover.

Research

Clinical Evidence

High confidence
Effective range N/A
Optimal

Formulations containing Salvia Officinalis Leaf Oil have demonstrated non-irritating and non-sensitizing effects in human tests at concentrations of 0.03% in a body lotion and 8% in petrolatum. Efficacious antioxidant activity has been observed in vitro at 5-15 mg/mL, and anti-inflammatory/antifungal activity up to 0.64 μL/mL. Optimal application percentages in finished products should adhere to regulatory thujone limits, typically allowing for safe and effective use within the 0.03% to 8% range.

Key findings

  1. 01 Exhibited significant DPPH radical scavenging (antioxidant) activity, achieving 73-77% inhibition at concentrations of 5, 10, and 15 mg/mL.
  2. 02 Demonstrated antifungal activity against dermatophyte strains and significantly inhibited nitric oxide (NO) production (anti-inflammatory) in macrophages at concentrations up to 0.64 μL/mL, without compromising cell viability.
  3. 03 A body lotion formulated with 0.03% Salvia Officinalis Oil was confirmed as non-irritating and non-sensitizing in Human Repeat Insult Patch Tests (HRIPTs) involving 53 subjects.
  4. 04 An 8% concentration of Salvia Officinalis Oil in petrolatum was found to be non-irritating and non-sensitizing in a 48-hour occlusive patch test and a maximization test with 25 subjects.

Transparency

Dusting Analysis

Not commonly dusted

As an essential oil, Salvia Officinalis Leaf Oil is typically formulated as a liquid and is not subject to dusting considerations.

The Formula

Formulation

Solubility
Oil
Optimal pH 4.5 – 7.5
0 7 14

Stability

The oil maintains its integrity and efficacy across typical cosmetic pH ranges, specifically performing well in systems between pH 4.5 and 7.5, which includes both acidic and neutral formulations.

Conflicts

  • Must not be applied undiluted to the skin, as it has been classified as a potential irritant and sensitizer in its concentrated form.
  • High concentrations of its terpene and terpenoid components can induce dermal sensitization.
  • Its strong aromatic profile may overwhelm or clash with more delicate floral scents if not precisely proportioned in fragrance compositions.

Safety

Safety Profile

CIR Status
Safe with restrictions
Max tested
8%
Sensitization risk Moderate

The CIR Expert Panel concludes Salvia Officinalis Oil is safe in cosmetic applications when formulated to be non-sensitizing and when thujone levels comply with regulatory restrictions. Undiluted oil has shown moderate irritation in animal studies and a low incidence of irritation in human patch tests. However, diluted concentrations of 0.03% and 8% have been proven non-irritating and non-sensitizing in human trials. Formulators are required to adhere to IFRA restrictions on thujone (a component of sage oil), with limits varying by product category (e.g., 0.0053% in certain skin contact products), to prevent irritation and sensitization. The FDA lists Salvia officinalis as Generally Recognized As Safe (GRAS) for specific uses.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Moderate
Comedogenicity Low

Our Assessment

Verdict

Valuable

Salvia Officinalis Leaf Oil is a valuable ingredient for its broad spectrum of antioxidant, anti-inflammatory, and antimicrobial benefits, provided it is precisely formulated within established safety concentrations and thujone limits.

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