Science
Mechanism of Action
Salvadora Persica Stem Extract operates through several pathways to support skin vitality. It is understood to bolster the skin's intrinsic antioxidative defense system, reduce proinflammatory cytokine activity, and modulate apoptotic pathways for healthy cell turnover. Its inherent anti-inflammatory, antimicrobial, antioxidant, and astringent properties collectively contribute to its role in promoting tissue repair and overall dermal healing.
Research
Clinical Evidence
Medium confidenceN/A
Transparency
Dusting Analysis
No data within the research suggests that Salvadora Persica Stem Extract is commonly subjected to 'dusting' practices in cosmetic formulations.
The Formula
Formulation
Stability
The extract exhibits solubility across a near-neutral pH range (PBS 6.4 and 7.4), with a 1% solution showing an approximate neutral pH. While cool water solubility is limited, it demonstrates partial solubility in hot water.
Safety
Safety Profile
No specific safety assessments from CIR, SCCS, or FDA were identified. A 1% solution of Salvadora persica bark extract was found to possess a near-neutral pH, suggesting a low likelihood of irritation at the application site at this concentration. However, it is crucial to note that in-vitro studies revealed cytotoxic effects on human dental pulp stem cells at higher concentrations (e.g., 5.75 mg/ml for water extract and 1.43-5.75 mg/ml for ethanolic extract), indicating that formulation concentrations should be carefully controlled.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Salvadora Persica Stem Extract is a valuable ingredient, demonstrating potent capabilities in promoting stem cell proliferation, exhibiting antimicrobial action, and offering anti-inflammatory and antioxidant benefits, though careful consideration of concentration is advised due to observed cytotoxicity at higher levels.
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References
Sources