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SALICYLOYL PHYTOSPHINGOSINE.

Valuable / SKIN CONDITIONING

This ceramide derivative actively targets signs of photoaging, reducing wrinkle depth and improving skin texture. It boosts vital ECM proteins while decreasing collagen-degrading enzymes.

anti-aging skin conditioning anti-inflammatory barrier support collagen boosting

Science

Salicyloyl Phytosphingosine stimulates collagen and fibrillin-1 production and reduces MMP-1, an enzyme that breaks down collagen. It also strengthens the skin barrier, provides anti-inflammatory benefits, and supports skin microflora balance.


Research

High confidence
Effective range 0.05–0.2%
Optimal

0.2%

Key findings

  1. 01 In vivo studies showed increased fibrillin-1 and procollagen-I, with reduced MMP-1 in photoaged skin at 0.05% and 0.2%.
  2. 02 Topical application reduces wrinkle depth and improves skin texture in photoaged skin.
  3. 03 A 4-week clinical study demonstrated clear reductions in wrinkle depth (Rz) and skin roughness (Ra) with an O/W cream.

Transparency

Not commonly dusted

This ingredient requires heating and specific solvents for complete dissolution in the oil phase, making it less prone to dusting issues than typical powder ingredients.


The Formula

Solubility
Oil
Optimal pH 6 – 8
0 7 14

Stability

Optimal stability is found in neutral pH conditions (6-8). It requires heating to 80-90°C and specific solvents like Octyldodecanol for complete dissolution in oil.

Conflicts

  • strong oxidizing agents

Safety

CIR Status
Not reviewed
Max tested
0.2%
Sensitization risk Low

Considered non-irritant and non-sensitizing, with adverse reactions being uncommon. Pregnancy and breastfeeding safety data is lacking, so consult a healthcare professional.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

A highly effective anti-aging ingredient that supports skin structure, reduces wrinkles, and improves overall skin health across all skin types.


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