Science
Mechanism of Action
Saccharomyces/Rice Extract Ferment Filtrate operates through multiple cellular pathways to revitalize the skin. It delivers essential nutrients and potent antioxidants, aiding in the reduction of inflammation and protection against environmental stressors. This ingredient directly supports dermal collagen synthesis, enhances elasticity, and strengthens the skin's natural barrier function for superior moisture retention. Furthermore, it harmonizes the skin's microflora, potentially contributing to gentle exfoliation, balancing oil production, and inhibiting melanin synthesis for a more even tone. Its fermented components improve nutrient bioavailability, and specific research indicates it can stabilize collagen mRNA by modulating HuR within the IL-17 signaling pathway.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 In an in vitro study, 0.25% Saccharomyces/Rice Extract Ferment Filtrate, when combined with 0.25% Sialic Acid, resulted in a significant 198% increase in collagen synthesis and a 20.8% elevation in COL1A1 expression within HFF-1 cells, surpassing the effects of either ingredient alone.
- 02 An 8-week application of a face cream containing Rice Ferment Filtrate demonstrated a statistically significant reduction in both the area and length of wrinkles around the eyes in human subjects.
- 03 In vitro research utilizing HaCaT cells revealed that a brown rice filtrate fermented with Saccharomyces cerevisiae markedly elevated hyaluronic acid levels and enhanced the expression of hyaluronan synthase 2 and aquaporin 3 (AQP3), both critical for maintaining skin hydration.
Transparency
Dusting Analysis
Effective concentrations for this ingredient are suggested to range from 0.01% to 5.0% by weight in cosmetic compositions for optimal efficacy and stability. While specific clinical efficacy concentrations for the ingredient alone are not always delineated, the recommended formulation range implies active benefits, making dusting below 0.01% a potential concern for product effectiveness.
The Formula
Formulation
Stability
This ingredient is readily biodegradable under aerobic conditions. For effective performance and optimal stability within cosmetic preparations, a concentration range of 0.01% to 5.0% by weight is preferred. It can be successfully formulated with conventional cosmetic adjuvants including antioxidants, stabilizers, solubilizers, vitamins, pigments, and flavorings.
Synergies
- Sialic Acid (enhanced collagen synthesis)
- Antioxidants
- Stabilizers
- Solubilizers
- Vitamins
Safety
Safety Profile
While a related ingredient, Saccharomyces Ferment Filtrate, is broadly considered safe for use in cosmetics at concentrations up to 5% in leave-on products, the CIR issued an 'Insufficient Data Announcement' in June 2023 for yeast-derived ingredients, specifically requesting additional dermal sensitization data. Despite this, the ingredient itself has demonstrated no detectable genotoxic activity in the Ames Test and no phototoxic reactions. The US FDA and European Cosmetics Regulation do not classify it as harmful, recommending adherence to manufacturer guidelines. A patch test is advised prior to comprehensive usage. Patent information suggests concentrations exceeding 5% may present challenges in formulation stability or safety.
Your Skin
Skin Compatibility
Our Assessment
Verdict
SACCHAROMYCES/RICE EXTRACT FERMENT FILTRATE is a valuable, multi-beneficial ingredient shown to significantly enhance collagen production, boost hydration, and improve overall skin texture across all skin types, contributing to a brighter, more resilient, and healthy-looking complexion.
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