Science
Mechanism of Action
The ingredient operates through a dual mechanism, combining the individual strengths of its fermented components. Saccharomyces Ferment Filtrate contributes essential nutrients, acts as an antioxidant, and helps mitigate inflammation. It supports collagen production, improves skin elasticity, refines texture, and minimizes the appearance of fine lines, while enhancing the skin's natural barrier for superior moisturization and soothing. The Prunus yedoensis Bark Extract component is instrumental in boosting hyaluronic acid synthesis and strengthening skin barrier proteins. It demonstrates potent antioxidant and anti-apoptotic effects, safeguarding against UVB-induced aging. Furthermore, it exhibits anti-inflammatory actions by inhibiting inflammatory cytokine synthesis and downregulating cell adhesion molecules, primarily through modulation of NF-κB, MAPK, and Akt pathways.
Research
Clinical Evidence
Medium confidence0.5%
Key findings
- 01 Prunus yedoensis Bark Water Extract, at concentrations of 0.5%, 1.0%, and 2.0%, demonstrated significant antioxidant and anti-apoptotic effects in human keratinocyte (HaCaT) cells, particularly against UVB radiation-induced aging.
- 02 A Prunus yedoensis bark ethanol extract (PYBEE) and its principal bioactive compound, naringenin, significantly upregulated hyaluronic acid (HA) expression and increased hyaluronic acid synthase-2 (HAS2) levels in cultured HaCaT keratinocytes, thereby enhancing epidermal barrier function.
- 03 Saccharomyces Ferment Filtrate is recommended for use between 0.1% and 5% in leave-on formulations, offering a broad spectrum of skin benefits including moisturization, soothing, and anti-aging.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
To maintain optimal efficacy, avoid exposing the ingredient to temperatures exceeding 60°C.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel issued an 'Insufficient Data Announcement' for yeast-derived ingredients, including various Saccharomyces ferments, specifically requesting confirmatory dermal sensitization data. However, Saccharomyces cerevisiae (the yeast typically used for fermentation) is Generally Recognized As Safe (GRAS) by the FDA for food use up to 5%. For the Prunus Yedoensis Bark Extract component, the EWG Skin Deep database indicates low concerns regarding cancer, allergies & immunotoxicity, developmental and reproductive toxicity, and use restrictions. The maximum recommended concentration for related Saccharomyces Ferment Filtrate in leave-on products is 5%.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This multifaceted fermented ingredient offers robust antioxidant, hydrating, and barrier-strengthening benefits, making it a valuable addition for comprehensive skin health and anti-aging regimens across all skin types.
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References
Sources