Science
Mechanism of Action
The Saccharomyces Ferment Filtrate component delivers essential vitamins, minerals, and amino acids, aiding in skin moisturization, barrier restoration, and soothing. It also exhibits antioxidant properties, stimulates regeneration, and helps regulate sebum while inhibiting melanin production for improved skin tone. Hexapeptide-11, a potent signaling peptide, activates cellular proteostasis networks, including proteasome and autophagy, and boosts antioxidant responses by enhancing Nrf2 accumulation. It upregulates genes critical for collagen and hyaluronic acid synthesis, ultimately promoting collagen and elastin formation, thereby synergistically strengthening the skin's extracellular matrix and reducing the appearance of wrinkles.
Research
Clinical Evidence
Medium confidence4%
Transparency
Dusting Analysis
As a ferment filtrate extract, this ingredient is typically supplied in liquid form and is not associated with dusting concerns, which are primarily relevant for powdered raw materials.
The Formula
Formulation
Stability
For optimal stability, this ingredient should be incorporated into formulations during the final manufacturing stage, ensuring the temperature remains below 40 °C. The optimal pH range for its active peptide component, Hexapeptide-11, is between 5 and 7.
Synergies
- Other ingredients supporting collagen and elastin production
- Antioxidants that combat free radicals
Safety
Safety Profile
While Hexapeptide-11 has demonstrated no toxicity in studies and Saccharomyces cerevisiae is generally recognized as safe (GRAS) for certain food uses, the CIR Expert Panel has categorized data for broader yeast-derived ingredients as insufficient for a definitive cosmetic safety determination for their intended uses. A patent suggests a maximum total concentration of 6 wt% for yeast extract and Hexapeptide-11 components in personal care compositions. Based on the safety profiles of its individual constituents, the overall sensitization risk is considered low, though comprehensive CIR assessment for the combined ingredient is not yet definitive.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This ingredient offers promising benefits for skin elasticity, firmness, and hydration, supported by mechanistic understanding and some clinical data for its components; however, its overall safety rating from the CIR Expert Panel remains 'insufficient data'.
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