Science
Mechanism of Action
The ingredient operates through a multi-faceted approach, leveraging the enhanced bioavailability of botanical compounds achieved via Saccharomyces fermentation. Asparagus cochinchinensis derivatives, such as Methyl Protodioscin and Aspacochioside C, mitigate inflammatory responses by inhibiting key cytokines and attenuate eumelanin synthesis by suppressing tyrosinase-related protein 2 (TRP2) expression. Fermented Panax ginseng further contributes to robust antioxidant defense, safeguarding skin cells from oxidative stress. This synergistic action targets inflammation, oxidative damage, and hyperpigmentation, fostering improved skin condition.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Specific compounds from Asparagus cochinchinensis, like Methyl Protodioscin, have demonstrated a dose-dependent inhibition of pro-inflammatory cytokines (IL-6, IL-8, TNF-α) at 10-100 µM in in vitro lung epithelial cells, and reduced inflammatory cell infiltration at 30-60 mg/kg in a murine model.
- 02 Aspacochioside C from A. cochinchinensis has been shown to attenuate α-MSH- and UVB-induced eumelanin production by inhibiting TRP2 protein expression in melanoma cells, concurrently reducing pigmentation density in zebrafish embryos.
- 03 Oligosaccharides derived from Asparagus cochinchinensis significantly reduced nitric oxide (NO) production and down-regulated inflammatory mRNA markers (IL-6, IL-1β, TNF-α) in immune cells, while also inhibiting intracellular reactive oxygen species (ROS) and ameliorating lung injury in a murine model.
- 04 A Saccharomyces cerevisiae fermented extract of Panax notoginseng exhibited enhanced antioxidant capacity and provided protection against hydrogen peroxide (H2O2)-induced oxidative stress in mouse skin fibroblasts, improving cell viability and enzyme activities (CAT, GSH-Px, SOD) while reducing ROS and malondialdehyde (MDA) levels.
Transparency
Dusting Analysis
As a ferment filtrate, this ingredient is typically supplied in liquid form, rendering the concept of dusting inapplicable.
The Formula
Formulation
Synergies
- The fermentation process is noted to enhance the bioavailability and efficacy of the constituent botanical compounds, leading to improved overall skin benefits.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel has not conducted a specific review of this particular complex ferment filtrate. While certain individual components, such as Panax Ginseng, have undergone review, a direct safety assessment for this precise combination of botanicals with Saccharomyces fermentation by major regulatory bodies like CIR, SCCS, or FDA is not available in the provided research. Consequently, a definitive maximum concentration for use has not been established.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This multi-botanical Saccharomyces ferment filtrate offers valuable benefits for skin conditioning, leveraging its antioxidant, anti-inflammatory, and potential brightening properties derived from its well-researched constituent plant extracts.
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References
Sources