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Moumoujus

SACCHARIDE ISOMERATE.

Valuable CAS 100843-69-4 / HUMECTANT

Saccharide Isomerate is a highly effective, skin-identical humectant engineered for profound and sustained hydration. It mimics the skin's natural moisturizing factor (NMF) to establish a lasting moisture reservoir, significantly bolstering the skin barrier.

Summary

Humectant Skin Hydrator Skin Barrier Fortifier Soothing Agent Skin-Conditioning Agent

Science

Mechanism of Action

This unique saccharide binds robustly to keratin fibers within the stratum corneum, specifically targeting free amino groups of lysine on keratinocytes. This creates a moisture reservoir that resists rinsing, providing continuous hydration for up to 72 hours, even post-cleansing. Its action strengthens the skin's protective barrier, diminishes transepidermal water loss (TEWL), and offers notable soothing and anti-irritant benefits to calm redness.

Research

Clinical Evidence

High confidence
Effective range 0.2–5%
Optimal

5%

Key findings

  1. 01 Demonstrated immediate and prolonged hydration, alongside positive impacts on the skin's protective barrier and overall moisture levels.
  2. 02 Outperformed 5% glycerin in moisture retention and delivered superior skin hydration compared to standard moisturizers, with benefits persisting even after product discontinuation.
  3. 03 Achieved significant scalp barrier repair within three days of application.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 4 – 5
0 7 14

Stability

Exhibits optimal stability within a pH range of 4-5. It is water-soluble and also soluble in ethanol, allowing for seamless integration into diverse cosmetic formulations.

Conflicts

  • Not recommended for co-formulation with primary amines in hand sanitizer gels due to the risk of Maillard reactions, although 1% Saccharide Isomerate has shown no adverse impact on color stability in such specific contexts.

Safety

Safety Profile

CIR Status
Safe as used
Max tested
5%
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has affirmed Saccharide Isomerate's safety in cosmetic applications at current usage levels and concentrations. It is generally well-tolerated with a minimal risk of irritation or sensitization. While no explicit CIR maximum concentration is set, clinical efficacy and safety studies support its use up to 5%.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Saccharide Isomerate is a valuable ingredient, delivering profound and persistent hydration while significantly enhancing the skin's barrier integrity across all skin types.

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