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Moumoujus

S-RICE OLIGOPEPTIDE-1.

Valuable / ANTIOXIDANT, BULKING

S-RICE OLIGOPEPTIDE-1 is an advanced biomimetic peptide designed to mimic Epidermal Growth Factor (EGF), a crucial cellular signaling molecule. It stimulates profound skin regeneration processes, enhances barrier function, and promotes the synthesis of vital structural proteins for comprehensive skin health and rejuvenation.

Summary

skin conditioning skin regeneration anti-aging barrier support skin texture improvement reduces fine lines reduces melasma reduces inflammatory acne improves skin elasticity enhances hydration

Science

Mechanism of Action

Functioning as a potent cellular signal, S-RICE OLIGOPEPTIDE-1 binds specifically to receptors on keratinocytes, initiating a cascade of cellular events that foster cell growth, proliferation, differentiation, and tissue repair. This mechanism actively enhances skin regeneration, fortifies the natural barrier, and stimulates the biosynthesis of key structural proteins like collagen and elastin. The outcome is improved skin texture, visible reduction of fine lines, enhanced microvascular generation, and increased production of extracellular matrix components, including hyaluronic acid.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Topical EGF serum applied twice daily for 8 weeks resulted in a 73% decrease in melasma in subjects with no reported side effects.
  2. 02 An EGF cream, used on half the face for six weeks, demonstrated a 33.5% reduction in inflammatory acne lesions in a study of 20 subjects.
  3. 03 A serum containing barley bioengineered epidermal growth factor showed statistically significant improvement in fine lines, rhytids, skin texture, pore size, and various dyschromatic conditions within one month of use, with continuous improvement over a 3-month study.
  4. 04 An EGF-containing cream significantly increased skin moisture and elasticity and decreased transepidermal water loss (TEWL) after one week, indicating improved skin barrier function.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 8
0 7 14

Stability

This peptide exhibits pH sensitivity; therefore, the cream's pH should be meticulously adjusted to a range of 5.0 to 8.0 prior to incorporating the diluted Oligopeptide-1 solution. To prevent enzymatic degradation, strict avoidance of microbial contamination is paramount.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

S-RICE OLIGOPEPTIDE-1, often analogous to human oligopeptide-1 (EGF), is classified as a potent unauthorized drug and is not permitted as a cosmetic raw material in certain regions (e.g., China) due to its high molecular weight and potential safety concerns. Regulatory claims of its inclusion or efficacy as EGF in cosmetics are illegal in such regions. Furthermore, there are ongoing discussions regarding whether sh-oligopeptide-1 is functionally equivalent to native EGF, and its long-term risks in cosmetic applications are considered partially unknown. However, sh-Oligopeptide-1 generally has a reported safe profile across numerous sources.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

S-RICE OLIGOPEPTIDE-1 is a valuable biomimetic peptide for advanced skin regeneration and anti-aging, demonstrating significant clinical benefits through its EGF-mimicking action, despite current regulatory nuances and functional clarifications needed in some global markets.

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