Science
Mechanism of Action
This ingredient functions as a potent skin-conditioning agent by acting as a signaling molecule that accelerates skin repair processes. It stimulates the proliferation of key skin cells, including keratinocytes, endothelial cells, and fibroblasts. This action enhances blood vessel formation, triggers the release of rejuvenating growth factors, and facilitates the healing of skin injuries without scarring. S-PEA Oligopeptide-1 SP also fortifies the skin barrier, reduces inflammatory responses, and significantly boosts the production of extracellular matrix components like collagen, elastin, and hyaluronic acid, delivering profound moisturization and contributing to visibly healthier, more resilient skin.
Research
Clinical Evidence
Medium confidence0.0035%
Transparency
Dusting Analysis
The Formula
Formulation
Stability
This ingredient is highly sensitive to pH variations. For optimal stability and efficacy, formulations should be precisely adjusted to a pH between 5.0 and 8.0 before the addition of its diluted solution.
Safety
Safety Profile
S-PEA Oligopeptide-1 SP is synthetically derived from the Pisum sativum plant and is considered bioequivalent to Epidermal Growth Factor (EGF). While authorized for cosmetic use, there are cautions regarding its EGF-mimetic properties: a review indicates potential unknown long-term risks and concern for tumorigenesis with overexpression or dysregulation, as EGF signaling is prevalent in many tumor cells, suggesting prudent use of EGF-mimetic personal care applications. Despite these considerations, EWG identifies low concerns for cancer, allergies, immunotoxicity, developmental and reproductive toxicity, and usage restrictions. SkinSAFE categorizes it as Teen SAFE, Baby SAFE, Eyelid SAFE, Irritant Free, and Common Preservative Free, with limited evidence of skin or eye irritation. There is no specific CIR, SCCS, or FDA safety assessment available under its exact name.
Your Skin
Skin Compatibility
Our Assessment
Verdict
S-PEA Oligopeptide-1 SP exhibits significant regenerative and anti-aging benefits in short-term studies; however, its EGF-mimetic nature and cited potential for unknown long-term risks, including tumorigenesis with dysregulation, necessitates a highly cautious approach in formulation and usage.
Related
Similar Ingredients
Finding similar ingredients…