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Moumoujus

S-PALMITOYLGLUTATHIONE.

Valuable / ANTIOXIDANT

S-Palmitoylglutathione is an advanced, lipophilic derivative of glutathione, precisely engineered to enhance skin penetration and deliver potent antioxidant, anti-aging, and barrier-strengthening benefits. It effectively combats oxidative stress, reduces the appearance of wrinkles, and improves overall skin vitality and texture.

Summary

antioxidant skin-identical ingredient anti-aging skin brightening skin barrier support anti-glycation

Science

Mechanism of Action

This ingredient functions as a robust antioxidant, actively neutralizing free radicals and mitigating oxidative damage to the skin. It significantly boosts transketolase activity by 300% and prevents protein glycation, thereby hindering Advanced Glycation End-product (AGE) formation. By inhibiting tyrosinase, S-Palmitoylglutathione also contributes to reducing hyperpigmentation and brightening skin tone. Its unique palmitoyl modification enhances lipophilicity, facilitating deeper penetration into the stratum corneum, replenishing vital keratinocyte lipids, and reinforcing the skin's natural moisture barrier for improved softness and hydration. Furthermore, it may optimize stratum corneum metabolism through cell signaling pathway regulation, leading to smoother skin.

Research

Clinical Evidence

High confidence
Effective range 1–3%
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

There is no available research indicating that S-Palmitoylglutathione is commonly 'dusted' in formulations, nor data defining a specific dusting threshold or associated red-flag percentages.

The Formula

Formulation

Solubility
Oil
Optimal pH 5 – 6
0 7 14

Stability

S-Palmitoylglutathione possesses a lipophilic structure, making it oil-soluble and capable of efficient cell membrane penetration. The palmitoyl groups augment its hydrophobicity, contributing to enhanced membrane association and stability. While compositions generally maintain stability within a pH range of 4.0 to 8.5, optimal stability is observed in a narrower range of 5.0 to 6.0.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

To date, no adverse side effects have been reported in clinical studies involving S-Palmitoylglutathione. It has not been specifically reviewed by the Cosmetic Ingredient Review (CIR) or the Scientific Committee on Consumer Safety (SCCS). While general discussions exist regarding glutathione's efficacy and safety as a skin lightener, these are not directly applicable to S-Palmitoylglutathione as a distinct ingredient.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

S-Palmitoylglutathione is a highly valuable ingredient, demonstrating significant clinical efficacy in reducing aging signs, enhancing skin barrier function, and providing robust antioxidant protection with excellent skin compatibility.

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