Science
Mechanism of Action
This biomimetic peptide acts as a highly selective modulator of neuromuscular transmission. It targets and blocks NaV 1.4 voltage-gated sodium channels at the neuromuscular junction, effectively inhibiting muscle fiber contraction. This targeted action reduces the formation of dynamic expression lines, similar to the effect of botox. Its high selectivity for muscle-specific NaV 1.4 channels minimizes interaction with other vital channels (e.g., NaV 1.5 in the heart), ensuring a favorable safety profile.
Research
Clinical Evidence
Medium confidence3%
Key findings
- 01 A manufacturer's in-vivo study involving a single application of a 3% concentration on 33 individuals demonstrated a visible and significant reduction in wrinkle depth and rugosity within 2 hours. Specifically, crow's feet depth was reduced by -9.5%. The study also noted prolonged efficacy for up to 24 hours, with a cumulative benefit observed over 28 days.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
This water-soluble peptide exhibits high bioactivity and enhanced stability. It is soluble in PBS at pH 7.2 with concentrations of ≥10 mg/ml and in H2O at 80 mg/mL, for which sonication is recommended during preparation.
Safety
Safety Profile
S-MU-CONOTOXIN CNIIIC ACETATE is noted for its high dermatological safety, being hypoallergenic, non-irritating, and non-sensitizing. Its highly selective mechanism of action, which targets muscle contractions without affecting other organs, contributes to its safety profile. No known side effects have been reported.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This precision biomimetic peptide is a valuable ingredient for effectively and safely reducing the appearance of expression lines across all skin types.
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