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Moumoujus

S-HIV-1 OLIGOPEPTIDE-1.

Valuable / NOT REPORTED

S-HIV-1 Oligopeptide-1 is a sophisticated, synthetically engineered peptide comprising 38 amino acids, structurally derived from the Human Immunodeficiency Virus-1 (HIV-1) TAT protein sequence. Recognized as a potent skin conditioning agent, it functionally mimics Epidermal Growth Factor (EGF) to stimulate profound cellular growth and renewal within the skin.

Summary

Epidermal Growth Factor Skin-identical ingredient Cell-communicating ingredient Wound healing Skin renewal

Science

Mechanism of Action

This peptide exerts its effects by selectively binding to epidermal growth factor (EGF) receptors present on the skin's surface. This interaction initiates a robust cascade of intracellular signals that enhance the proliferation and differentiation of epidermal cells, thereby driving significant skin regeneration and repair. Furthermore, it actively promotes collagen synthesis, which contributes to improved skin firmness and elasticity, and exhibits anti-inflammatory properties to support the skin's intrinsic healing mechanisms.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Stability

The ingredient is susceptible to decomposition by enzymes produced by microorganisms, which can lead to a loss of activity. Optimal product stability and precise formulation are critical to maximize its efficacy and mitigate potential adverse effects.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

S-HIV-1 Oligopeptide-1 is synthetically produced based on a pathogenic Human Immunodeficiency Virus-1 (HIV-1) protein sequence. While active EGF is considered an unauthorized drug, functionally similar sh-EGF (sh-oligopeptide-1) is approved for cosmetic use in various concentrations, though its long-term risks are not fully understood. Experts confirm EGF is mitogenic (stimulates cell proliferation) but not mutagenic (does not cause cancer if not already present). Individuals with psoriasis or an elevated risk of skin cancer are advised to exercise caution. Oligopeptide-1, often used interchangeably, is not listed on EWG's Restricted or Unacceptable Lists and is considered unlikely to be carcinogenic in humans.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

S-HIV-1 Oligopeptide-1 is a valuable biomimetic peptide, offering significant potential for skin regeneration, repair, and anti-aging benefits by mimicking EGF. However, its viral sequence origin and advisories for specific health conditions necessitate a precise and informed approach to its use.

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