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S-ARACHIDONOYL/LINOLENOYL/LINOLEOYL GLUTATHIONE.

Valuable / ANTIOXIDANT

This advanced S-acyl glutathione derivative combines the potent antioxidant properties of glutathione with the skin-benefiting fatty acids arachidonic, linolenic, and linoleic acids. It is engineered to deliver comprehensive protection against oxidative stress while supporting vital skin barrier functions.

Summary

Antioxidant Skin Barrier Support Free Radical Scavenger Anti-aging Photoprotection

Science

Mechanism of Action

S-ARACHIDONOYL/LINOLENOYL/LINOLEOYL GLUTATHIONE functions primarily as a robust antioxidant, actively inhibiting oxygen-promoted reactions to prevent ingredient deterioration and cellular damage. The linoleoyl component specifically introduces linoleic acid, which is crucial for maintaining a healthy skin barrier. This compound acts as a free radical scavenger and is implicated in triggering sirtuin upregulation, thereby enhancing the skin's defense mechanisms against oxidative stress and reducing DNA damage by boosting cellular glutathione levels.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 A clinical trial utilizing a related compound, 2% S-linolenoyl glutathione (Lin-GSH) cream, demonstrated a significant increase in the Minimal Erythema Dose (MED) when compared to a placebo. This indicated potent antioxidant capabilities and a favorable safety profile, with no reported grade 3-4 adverse events.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

The presence of fatty acid chains alongside the glutathione component suggests an amphiphilic nature, likely enhancing lipid penetration. While direct stability data for this specific derivative is limited, related glutathione compounds exhibit restricted stability in aqueous solutions, often not recommended for prolonged storage, especially around pH 7.2. Formulations such as proliposomes have been explored to improve the stability and bioavailability of glutathione derivatives.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

No specific review by CIR, SCCS, or FDA has been identified. However, INCI Beauty indicates a 'Low penalty' across all safety categories for this ingredient. Furthermore, a related compound, S-linolenoyl glutathione, demonstrated a safe topical application profile at 2% concentration in a clinical trial, reporting no grade 3-4 adverse events, suggesting a favorable safety outlook.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

S-ARACHIDONOYL/LINOLENOYL/LINOLEOYL GLUTATHIONE is a valuable ingredient, leveraging glutathione's antioxidant power and fatty acid benefits to offer comprehensive skin protection and barrier support with a favorable safety profile.

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