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Moumoujus

RUTA GRAVEOLENS OIL.

Avoid CAS 8014-29-7 / 84929-47-5 / FRAGRANCE

Ruta Graveolens Oil, derived from the rue plant, is primarily utilized for its distinctive aromatic profile and skin-conditioning attributes. Its complex composition, featuring coumarins, flavonoids, and volatile oils, suggests potential antioxidant and antimicrobial properties. However, its application in skincare is strictly regulated due to significant phototoxicity concerns associated with its furocoumarin content.

Summary

Fragrance Perfuming Antioxidant Antimicrobial Skin Conditioning Melanin Promoter

Science

Mechanism of Action

This oil contributes to skin conditioning and may enhance texture, a characteristic attributed to its rich array of bioactive compounds including coumarins, alkaloids, and phenolic acids. Its antioxidant activity, notably from furanocoumarins and flavonoids, is postulated to counteract free radicals, which may contribute to its suggested soothing and antimicrobial actions.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In vitro studies indicated that polarity fractions of Ruta graveolens, at concentrations between 10-50 µg/mL, promoted melanin production in melanocytes without observed cytotoxic effects at 50 µg/mL.
  2. 02 A 5% methanol extract of Ruta graveolens demonstrated significant wound healing activity in rat models.
  3. 03 Ruta graveolens essential oil exhibited antifungal properties against various Candida species (e.g., C. tropicalis at 4.2 µg/mL, C. albicans at 8.2 µg/mL, C. glabrata at 131-66 µg/mL, C. parapsilosis at 4.1-16.4 µg/mL).

Transparency

Dusting Analysis

Commonly dusted

Due to stringent regulatory limits (e.g., total furocoumarins not exceeding 1 ppm in the finished product and the oil itself restricted to 0.15% in leave-on UV-exposed products), incorporating Ruta Graveolens Oil at concentrations capable of delivering significant clinical benefits beyond its aromatic profile is highly challenging. Consequently, any substantial functional claims made for this ingredient in compliant formulations are likely indicative of 'dusting'.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Avoid high concentrations in formulations intended for sun exposure due to phototoxicity.

Conflicts

  • High concentrations in products exposed to sunlight

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
0.15%
Sensitization risk High

Ruta Graveolens Oil is a restricted cosmetic ingredient under European Cosmetics Regulation 1223/2009 (Annexes III/358a); the total concentration of furocoumarin-like substances in the finished product must not exceed 1 ppm. The International Fragrance Association (IFRA) limits the essential oil to 0.15% in leave-on products with potential UV exposure due to its phototoxic potential. Caution is imperative with sun exposure, as high concentrations can induce phototoxicity.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
Yes Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Given its high irritancy, pronounced phototoxicity risk, and strict regulatory limits that severely constrain its functional concentration, Ruta Graveolens Oil is advised against for inclusion in precision skincare formulations, especially in leave-on products intended for UV exposure.

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