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Moumoujus

ROYAL JELLY EXTRACT.

Valuable CAS 91081-56-0 / SKIN CONDITIONING

Royal Jelly Extract is a nutrient-rich ingredient derived from bees, celebrated for its multifaceted benefits in skincare. It delivers intensive hydration and barrier support while actively stimulating collagen and elastin synthesis, addressing visible signs of aging. Additionally, its anti-inflammatory and antimicrobial properties contribute to a calm, resilient complexion.

Summary

Skin Conditioning Humectant Antioxidant Soothing Anti-inflammatory Anti-aging Barrier Support Antimicrobial

Science

Mechanism of Action

Royal Jelly Extract fortifies the skin barrier by supplying essential amino acids and natural moisturizing factors, thereby enhancing water retention and minimizing transepidermal water loss. Its humectant properties mimic hyaluronic acid, binding moisture within skin tissues. Key constituents, including Major Royal Jelly Proteins (MRJPs) and 10-Hydroxy-2-decenoic acid (10-HDA), stimulate cellular regeneration, collagen, and elastin production, which underlies its anti-aging efficacy. It also offers antioxidant protection against environmental stressors, exhibits anti-inflammatory effects by reducing irritation, and provides antimicrobial benefits that support wound healing and fight acne-causing bacteria. Cellularly, it upregulates NQO1 expression to combat epidermal stress and accelerates keratinocyte proliferation via the Akt/mTOR/HIF-1α pathway.

Research

Clinical Evidence

Medium confidence
Effective range 0.5–5%
Optimal

2%

Key findings

  1. 01 Topical formulations containing at least 2-5% Royal Jelly Extract yield meaningful benefits, notably an increase in collagen production.
  2. 02 In a cream formulation, 0.5% 10-Hydroxy-2-decenoic acid (10-HDA), a primary component of royal jelly, stimulated skin whitening in mouse models.
  3. 03 A cream formulated with 10-HDA significantly boosted skin hydration by 28.8% after 7 days and 60.4% after 21 days of treatment.

Transparency

Dusting Analysis

Commonly dusted
Min. effective
2%
Red flag below
1%

While specific components like 10-HDA show efficacy at 0.5% for targeted benefits like hydration or whitening, broader anti-aging benefits, particularly collagen production, are indicated at concentrations of 2% or higher. Formulations featuring Royal Jelly Extract below this 2% threshold for comprehensive claims may be underdosed, potentially limiting overall efficacy despite remaining within typical safe concentration ranges (0.1% to 5%).

The Formula

Formulation

Solubility
Water
Optimal pH 4 – 7.5
0 7 14

Stability

Royal Jelly Extract should be stored in a dry, closed container at room temperature, protected from direct light, humidity, high temperatures, and extreme pH conditions. While the extract is generally water-soluble, some powder forms may exhibit partial solubility. The natural pH of royal jelly itself ranges from 3.5-4.5.

Safety

Safety Profile

CIR Status
Safe as used
Max tested
5%
Sensitization risk Moderate

Generally safe for cosmetic use up to 5%, with a low EWG hazard rating and EU COSING approval for skin conditioning. However, as a bee-derived ingredient, it carries a moderate risk of allergic reactions (e.g., rashes, itching, irritation, redness) in individuals sensitive to bee products or pollen. Patch testing is strongly advised prior to use. It is unsuitable for vegan formulations due to its animal origin.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Royal Jelly Extract is a valuable, multi-functional ingredient providing significant benefits in hydration, anti-aging, and skin barrier support, though awareness of potential allergic sensitivities is crucial.

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