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Moumoujus

ROSA RUGOSA ROOT EXTRACT.

Valuable CAS 92347-25-6 / SKIN CONDITIONING

Rosa Rugosa Root Extract is a multi-functional botanical ingredient recognized for its potent antioxidant, anti-inflammatory, and skin-conditioning properties. Rich in polyphenols and flavonoids, it offers comprehensive benefits for skin health and resilience.

Summary

Antioxidant Anti-inflammatory Skin conditioning Humectant Astringent Skin barrier support Anti-aging

Science

Mechanism of Action

This extract functions primarily as an antioxidant by efficiently neutralizing free radicals and mitigating oxidative stress, a process largely attributed to its high concentration of polyphenols, flavonoids, phenolic acids, and Vitamin C. Its anti-inflammatory capabilities stem from triterpenoids, which contribute to soothing the skin and alleviating inflammatory responses. Rosa Rugosa Root Extract also fortifies the skin barrier through the induction of keratinocyte differentiation and upregulation of key proteins like filaggrin (FLG), involucrin (IVL), loricrin (LOR), and claudin1 (CLDN1). Furthermore, it demonstrates anti-aging potential by influencing GDF11 and PGC1alpha expression, thereby enhancing cellular metabolism and longevity in aged fibroblasts, which can result in reduced fine lines, stimulated collagen production, and diminished MMP-1 secretion. It also acts as a humectant for hydration and a natural astringent to refine pores.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Demonstrated 45% antioxidant activity in human keratinocytes in vitro.
  2. 02 Exhibited 60% antioxidant activity in human keratinocytes in vitro, with no observed cytotoxicity up to 10 μg/ml.
  3. 03 Achieved 82% antioxidant activity in human keratinocytes in vitro.
  4. 04 Phenolic compounds derived from Rosa rugosa flower buds effectively reduced intracellular reactive oxygen species (ROS) in TNF-α-induced human dermal fibroblasts.
  5. 05 Showcased strong radical scavenging capabilities and inhibitory effects on total lipid accumulation and triglyceride levels in differentiated mouse preadipocytes.

Transparency

Dusting Analysis

Not commonly dusted

Insufficient data available to determine if this ingredient is commonly 'dusted' or to establish a dusting threshold percentage. The available research focuses on its mechanism and efficacy rather than common formulation percentages.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Specific stability notes are not detailed in the provided research, but as a water-soluble botanical extract, general best practices for botanical preservation and formulation pH should be considered.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has not specifically evaluated Rosa Rugosa Root Extract. However, related Rosa species derivatives have been assessed, and in vitro studies on Rosa rugosa extract indicated no cytotoxicity up to 10 μg/ml in human keratinocytes. General safety assessments from sources like EWG Skin Deep suggest low concerns regarding cancer, allergies, immunotoxicity, and developmental/reproductive toxicity for Rosa Rugosa Flower Extract, with Rosa Rugosa Flower Oil noted for low irritation.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Rosa Rugosa Root Extract is a valuable ingredient, demonstrating strong in vitro antioxidant, anti-inflammatory, and barrier-enhancing properties across various skin types, supported by generally low safety concerns.

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