Science
Mechanism of Action
This extract acts as a robust antioxidant by actively neutralizing free radicals, bolstering the activity of superoxide dismutase, and mitigating DNA damage induced by oxidative stress. It contains high levels of vitamin C, polyphenols, flavonoids, and triterpenoids, which are key contributors to its protective capacity. Beyond antioxidant actions, it provides anti-inflammatory benefits by reducing itchiness and redness and suppressing inflammatory mediators like IL-8 in keratinocytes. Its anti-aging efficacy stems from promoting cell proliferation, improving the morphology of senescent cells, delaying cellular senescence, and supporting DNA replication and telomere maintenance pathways. It also contributes to evening skin tone and enhancing hydration, glossiness, and elasticity.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Demonstrated significant increases in telomerase activity and enhanced antioxidative capacity in human mesenchymal stem cells. This included reducing reactive oxygen species, boosting superoxide dismutase activity, minimizing DNA damage, promoting cell proliferation, improving senescent cell morphology, delaying replicative cellular senescence, attenuating cell cycle suppressors, and alleviating the senescence-associated secretory phenotype.
- 02 Successfully reduced reactive oxygen species levels and significantly enhanced antioxidative capacity within human mesenchymal stem cells.
- 03 In an 8-week human clinical trial, participants experienced significant improvements: skin hydration increased by 69.02%, glossiness by 30.48%, elasticity by 25.97%, and skin tone by 7.52%. Concurrently, skin firmness decreased by 21.17% and melanin levels by 25.06%.
Transparency
Dusting Analysis
There is no available data to suggest that Rosa Roxburghii Fruit Extract is commonly 'dusted' at ineffective concentrations in formulations.
The Formula
Formulation
Stability
The superoxide dismutase (SOD) activity within Rosa roxburghii fruits exhibits good stability in a temperature range of 40-60 °C and an alkaline pH between 7.8 and 8.0. However, fermentation broths of the fruit are typically acidic (pH 4-5). High concentrations of Cu2+ and Zn2+ can inhibit SOD activity, while moderate concentrations of Zn2+ (2-6 mmol/L) can have a stabilizing effect. Processed powder extracts are designed to dissolve clearly in water, with methods available to prevent caking and reduce astringency for enhanced applicability.
Conflicts
- High concentrations of Cu2+
- High concentrations of Zn2+
Safety
Safety Profile
Direct cosmetic safety assessments by CIR or SCCS for Rosa Roxburghii Fruit Extract are currently unavailable. While some *Rosa* species have GRAS status for food, this does not directly apply to cosmetic use of *R. roxburghii*. SkinSAFE rates the extract as '100 Free,' suggesting a low risk for common allergens and general suitability for sensitive skin. However, INCI Decoder indicates a 'medium' irritancy, suggesting some potential for skin irritation in certain individuals. In vitro studies confirm the fruit juice is not mutagenic, cytotoxic, or genotoxic, and provides protection against oxidative stress.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Rosa Roxburghii Fruit Extract is a valuable ingredient, demonstrating potent antioxidant and anti-aging effects in cellular models, alongside promising skin health improvements from oral supplementation, making it a strong candidate for comprehensive skin revitalization.
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