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Moumoujus

ROSA MULTIFLORA ROOT EXTRACT.

Valuable CAS 97593-51-6 / HAIR CONDITIONING, SKIN CONDITIONING

Rosa Multiflora Root Extract is a botanical active celebrated for its potent antioxidant, anti-inflammatory, and immune-modulatory properties. Derived from the root of the multiflora rose, this extract is particularly indicated for soothing sensitive and reactive skin conditions, including the management of atopic dermatitis.

Summary

Antioxidant Anti-inflammatory Immune-modulatory Skin conditioning Photoprotective

Science

Mechanism of Action

This extract operates through a multifaceted mechanism, leveraging its rich composition of ellagitannins, flavonoids (such as quercitrin), Vitamin C, and other tannins. It actively neutralizes free radicals, thereby mitigating oxidative stress on skin cells. Furthermore, it exerts significant anti-inflammatory action by suppressing key pro-inflammatory mediators such as interleukin-6 (IL-6), interleukin-8 (IL-8), TNF-alpha, inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2). For skin aging concerns, it inhibits matrix metalloproteinase (MMP) expression, which helps to preserve collagen and combat UV-induced photoaging. Its immune-modulatory effect is observed through the upregulation of interleukin-10 (IL-10), crucial for alleviating atopic dermatitis symptoms.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Topical application of Rosa multiflora root extract significantly ameliorated atopic dermatitis-like skin lesions in NC/Nga mice. This effect was linked to reduced mRNA levels of iNOS and COX-2 in skin tissues, alongside a substantial reduction in T helper 2 (Th2) immune responses, mediated by interleukin-10 (IL-10) upregulation.
  2. 02 General Rosa multiflora extract (not specifically from the root) protected human fibroblasts from UV-induced damage in an in vitro study.
  3. 03 Ethanol extracts from Rosa multiflora flowers (not root) significantly decreased reactive oxygen species (ROS), IL-6, IL-8, and MMP-1 levels in keratinocytes and dermal fibroblasts after UV irradiation, indicating protective effects from UV-induced photoaging in vitro.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Rosa multiflora root extract is listed with a UNII (6X8YF4S72T) by the FDA, indicating it is tracked. However, a specific GRAS (Generally Recognized as Safe) status for cosmetic use or a comprehensive CIR (Cosmetic Ingredient Review) assessment for this specific root extract is currently unavailable. While other Rosa species have undergone CIR review, Rosa multiflora root extract has not been specifically evaluated.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Rosa Multiflora Root Extract is a valuable ingredient, especially for sensitive and reactive skin types due to its substantiated antioxidant, anti-inflammatory, and immune-modulatory actions, though comprehensive human efficacy and safety data are still developing.

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