Science
Mechanism of Action
Rosa Multiflora Extract exerts its effects through a multifaceted approach. Its high concentration of Vitamin C, quercetin, lycopene, flavonoids, and polyphenols provides potent antioxidant capabilities, neutralizing reactive oxygen species (ROS) and thereby protecting skin from UV-induced photoaging. It actively suppresses the production of proinflammatory cytokines (IL-6, IL-8, TNF-alpha) and matrix metalloproteinases (MMP-1, MMP-13), key contributors to skin degradation. Furthermore, it demonstrates anti-inflammatory action by inhibiting iNOS and COX-2. Evidence suggests an AMPK-dependent mechanism helps in mitigating oxidative stress, promoting autophagy, protecting against cellular senescence, and maintaining skin health under stress. The extract also contributes to collagen synthesis and aids in reducing the appearance of dark spots and hyperpigmentation.
Research
Clinical Evidence
Medium confidence1%
Key findings
- 01 Effective at a 1-3% concentration in liquid formulations for reducing visible signs of photoaging (sun damage).
- 02 Ethanol extract of Rosa multiflora flowers provided protective effects against UV-induced photoaging in skin cells (keratinocytes, dermal fibroblasts) and hairless mice by suppressing ROS generation, proinflammatory cytokine production (IL-6, IL-8, TNF-alpha), and matrix metalloproteinase expression (MMP-1, MMP-13).
- 03 Rosa multiflora root extract topically improved atopic dermatitis-like skin lesions in mice by suppressing iNOS and COX-2 mRNA levels and reducing Th2 immune responses via IL-10 up-regulation.
- 04 Water, hexane, and ethyl acetate fractions of R. multiflora fruit extract demonstrated significant DPPH radical scavenging activity (up to 82.93%), with the ethyl acetate fraction showing greater activity than BHT.
Transparency
Dusting Analysis
Clinical data suggests an effective range of 1-3% for reducing signs of photoaging. Formulations using Rosa Multiflora Extract below 1% for this specific active benefit may be considered underdosed, potentially limiting its full efficacy.
The Formula
Formulation
Stability
Often supplied as a liquid in a base of water and butylene glycol. As a natural extract, its stability may be sensitive to light, air, and temperature fluctuations. Careful formulation and packaging are crucial to maintain its efficacy and prevent aesthetic issues.
Conflicts
- Other problematic ingredients (may increase irritation risk)
Safety
Safety Profile
No specific CIR report, SCCS, or FDA status was found for Rosa Multiflora Extract. While INCIDecoder rates its irritancy as low, some sources indicate a likelihood of irritation, inflammation, or dryness that may increase when combined with other problematic ingredients. Generally considered non-irritating on its own.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Rosa Multiflora Extract is a valuable ingredient, offering comprehensive antioxidant, anti-inflammatory, and anti-aging benefits, particularly in mitigating photoaging and promoting skin health, with a generally low risk of irritation.
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