Science
Mechanism of Action
This extract confers benefits through its rich composition of bioactive compounds, including flavonoids (e.g., quercetin, kaempferol) and phenolic compounds (e.g., gallic acid, ellagic acid), which exert potent antioxidant effects by neutralizing oxidative stress and protecting against environmental damage. It also exhibits anti-aging properties by supporting skin rejuvenation. Research on related rose extracts indicates the activation of the AMP-activated protein kinase (AMPK) pathway, which enhances cellular antioxidant defenses (NRF2 induction by ≈2–4%) and promotes autophagy (LAMP2A induction by ≈6–12%) in human keratinocytes. This mechanism contributes to protecting skin cells from oxidative damage, mitigating carbonylation levels (≈34–37% protection), and reducing senescent cells (p16INK4A cells by ≈60–72%) under pollution and UV-A induced stress. Furthermore, it demonstrates anti-inflammatory activity by reducing solar UV-induced COX-2 expression and cytokine production, linked to its rich content of anthocyanins, polyphenols, and flavonoids.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Typical use levels for related Rosa Hybrid Flower Extract range from 0.5% to 5% in emulsions, associated with anti-aging properties and luxury cosmetic formulations.
- 02 An unspecified rose extract (likely petal-derived) at 0.005% was shown to protect skin against stress mediators and clinically improve under-eye bags and dark circles in ex vivo and in vivo studies. This concentration was 10 to 100 times more potent than its active in vitro concentration.
- 03 A Rosa hybrid Extract (petal-derived) activated the AMPK pathway in human keratinocytes, resulting in a ≈2–4% induction of NRF2 levels and a ≈6–12% induction of LAMP2A levels. It provided ≈34–37% protection against carbonylation and ≈60–72% protection against p16INK4A cells induced by pollution and UV-A, indicating significant protection against oxidative damage, senescence, and support for cellular proteostasis and proliferation.
Transparency
Dusting Analysis
While a specific rose petal extract demonstrated targeted efficacy at 0.005% for certain benefits like under-eye improvements, the broader anti-aging and conditioning properties attributed to rose extracts typically see inclusion rates ranging from 0.5% to 5%. Concentrations significantly below 0.005% would be a red flag if specific, clinically demonstrated benefits are claimed, otherwise, lower percentages might still contribute to general skin conditioning.
The Formula
Formulation
Stability
The active components, such as anthocyanins found in rose petals, are water-soluble pigments, and their stability can be pH-dependent. Rose extracts are typically formulated in water and glycerin, indicating good dispersibility and stability within aqueous systems.
Conflicts
- General rose extracts may contain fragrance components (e.g., citronellol, geraniol, eugenol, limonene, linalool, farnesol, benzyl alcohol) that are recognized as potential sensitizers, necessitating careful formulation to ensure non-sensitizing cosmetic products.
- Methyl eugenol, a component potentially present in some rose extracts, is subject to specific EU regulatory restrictions on maximum concentration in leave-on products (e.g., 0.0002%).
Safety
Safety Profile
Direct safety assessments by CIR, SCCS, or FDA for ROSA HYBRID OVARY EXTRACT are not explicitly available. However, CIR has reviewed related rose extracts (Rosa centifolia, Rosa canina, Rosa damascena), concluding they are safe when formulated to be non-sensitizing. Concerns include potential sensitizers inherent to rose extracts such as citronellol, geraniol, and methyl eugenol; the latter has regulatory concentration limits (e.g., 0.0002% in leave-on products). The FDA lists essential oils and extracts of Rosa centifolia and Rosa damascena as Generally Recognized As Safe (GRAS) for food use. EWG Skin Deep identifies 'Rosa Hybrid Flower Extract' as 'Restricted' for EWG VERIFIED products without adequate substantiation, noting low general concerns for cancer, allergies & immunotoxicity, developmental and reproductive toxicity, but highlighting use restrictions.
Your Skin
Skin Compatibility
Our Assessment
Verdict
ROSA HYBRID OVARY EXTRACT is a valuable botanical ingredient, offering potent antioxidant defense, cellular longevity support, and soothing hydration, making it ideal for anti-aging and sensitive skin formulations when potential sensitizing components are carefully managed.
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