ROSA HYBRID CALLUS CULTURE EXTRACT.

This multifaceted extract exerts its effects by activating the AMP-activated protein kinase (AMPK) pathway. This activation leads to a significant increase in NRF2 (NF-E2-related factor 2) levels, thereby boosting the skin's intrinsic antioxidant capabilities. Concurrently, it elevates LAMP2A (Lysosome-Associated Membrane Protein 2A) levels, actively promoting cellular autophagy. This dual action effectively shields skin cells from oxidative damage and delays cellular senescence, crucial for maintaining cellular integrity, proteostasis, and the skin's regenerative capacity under stress. Beyond these core longevity pathways, it also acts as a humectant and skin protector, with demonstrated potential to soothe irritation, reduce redness, improve hydration and elasticity, and support skin regeneration. Furthermore, preliminary research suggests it may modulate skin olfactory receptors, potentially mediating an appeasing effect to counteract stress responses.