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Moumoujus

ROSA DAMASCENA CALLUS.

Essential / ANTI-SEBUM, ANTIMICROBIAL, ANTIOXIDANT, HAIR CONDITIONING, SKIN PROTECTING

Rosa Damascena Callus refers to the undifferentiated plant cells of the Damask Rose, cultivated for their potent bioactives. This innovative extract promotes skin regeneration and vitality, delivering comprehensive benefits including anti-aging, soothing, and brightening effects. It harnesses the plant's robust defense mechanisms to protect and revitalize human skin cells.

Summary

Antioxidant Anti-inflammatory Skin Regenerating Rejuvenating Anti-aging Skin Brightening Humectant Skin Protecting Wound Healing Collagen Boosting Anti-acne

Science

Mechanism of Action

Rosa Damascena Callus Culture Extract operates on multiple cellular pathways to improve skin health. It actively protects skin cell longevity and enhances their vitality, thereby promoting the regeneration of epidermal cells. Its anti-inflammatory action is evidenced by a significant reduction in pro-inflammatory cytokines like IL-6. As an antioxidant, it neutralizes free radicals and boosts intrinsic antioxidant enzyme activity. Furthermore, it contributes to improved skin hydration and elasticity, evens out skin tone by regulating melanogenesis, and supports extracellular matrix remodeling for anti-wrinkle and brightening effects, while also exhibiting anti-acne potential.

Research

Clinical Evidence

High confidence
Effective range 0.05–0.5%
Optimal

0.5%

Key findings

  1. 01 In vitro studies utilizing Rosa damascena solid state fermentation liquid (RDF) and water extract (RDE) at concentrations between 0.05% and 0.5% demonstrated efficacy in skin bleaching, antioxidant activity, anti-wrinkling, and soothing, with 0.5% RDF showing the most pronounced effects.
  2. 02 Further research on Rosa damascena Stem Cell-Derived Exosomes (RSCE), originating from callus stem cells, indicated substantial benefits in dermatological wound healing and scar management. RSCE enhanced fibroblast proliferation and migration, accelerated wound closure, and reduced scar contracture. It also improved skin elasticity and hydration, exerted anti-inflammatory effects by reducing IL-6 levels by 50-60% in stimulated macrophages, and increased collagen production by 40-120% in a dose-dependent manner.

Transparency

Dusting Analysis

Not commonly dusted

Insufficient data available to determine if this ingredient is commonly dusted in formulations.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Rosa Damascena Callus extracts are often formulated in glycerin and can be designed to be preservative-free. While callus induction media may utilize pH values around 5.7-6.0 for cell growth, specific stability data for the extract within cosmetic formulations is not extensively detailed.

Safety

Safety Profile

CIR Status
Safe with restrictions
Sensitization risk Low

The CIR Expert Panel has deemed Rosa damascena-derived ingredients, including callus culture extract, safe for cosmetic use when incorporated into formulations designed to be non-sensitizing.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Essential

Rosa Damascena Callus is an essential multifaceted ingredient, offering significant regenerative, anti-inflammatory, antioxidant, and anti-aging benefits for comprehensive skin rejuvenation and health.

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