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Moumoujus

RICE SH-POLYPEPTIDE-9.

Valuable / SKIN CONDITIONING

RICE SH-POLYPEPTIDE-9 is a bio-engineered peptide, a synthetic analog of human Vascular Endothelial Growth Factor A (VEGFA) produced using rice. It functions as a potent cell signaling protein, designed to invigorate skin’s regenerative processes and enhance microcirculation for healthier, more resilient skin.

Summary

Cell-communicating Stimulates blood vessel formation (Angiogenesis) Supports fibroblast cells with nutrients Aids in cell growth and migration Promotes wound healing Anti-wrinkle Skin rejuvenation Enhances elasticity Moisturizing Cell vitalization

Science

Mechanism of Action

Functioning as a cell-communicating protein, RICE SH-POLYPEPTIDE-9 stimulates angiogenesis, the formation of new blood vessels, by binding to specific receptors on endothelial cells. This process enhances nutrient and oxygen delivery to dermal layers, improving microcirculation and promoting healthier skin. It supports cell proliferation and migration, boosts the production of proteins vital for cell restructuring, leading to smoother and firmer skin. Furthermore, it protects endothelial cells from oxidative stress by reducing interleukin-1α (IL-1α) levels, aids in the survival of newly formed blood vessels, and supplies fibroblast cells—critical for collagen production—with essential nutrients, fostering wound healing and cellular growth.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

While a precise optimal pH range for RICE SH-POLYPEPTIDE-9 stability in cosmetic formulations is not specified, peptides generally exhibit sensitivity to both pH and temperature variations. It is typically supplied in liquid or freeze-dried powder forms, indicating its water solubility.

Conflicts

  • Individuals with psoriasis should avoid personal care products containing SH-Polypeptide-9 (VEGFA), as its activity may contribute to the progression of this condition.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

RICE SH-POLYPEPTIDE-9 is a synthetic recombinant human peptide produced via fermentation using rice. While the Cosmetic Ingredient Review (CIR) Expert Panel has assessed general categories of 'Tissue-Derived Proteins and Peptides' and 'Plant-Derived Proteins and Peptides' as safe, RICE SH-POLYPEPTIDE-9 has not undergone a dedicated individual safety review by the CIR, and thus no specific maximum concentration has been established. It is not currently found on EWG's Skin Deep Restricted or Unacceptable Lists, and no specific SCCS or FDA status was identified. Its irritancy and comedogenicity are currently unknown.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

RICE SH-POLYPEPTIDE-9 is a valuable bio-engineered peptide that supports skin regeneration, microcirculation, and structural integrity through its VEGFA-mimicking action, though specific clinical dosage and individual safety assessment by regulatory bodies are pending.

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