Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

RICE SH-OLIGOPEPTIDE-2.

Valuable / HUMECTANT, OPACIFYING, SKIN CONDITIONING

RICE SH-OLIGOPEPTIDE-2 is a precision biomimetic peptide, structurally analogous to proinsulin, functioning as an Insulin-like Growth Factor (IGF-1) to profoundly revitalize skin. It actively promotes cellular regeneration, stimulates vital collagen synthesis, and reinforces the skin's protective barrier, leading to a visibly smoother and more youthful complexion. Its multi-faceted action also supports enhanced wound healing and optimized hydration.

Summary

skin conditioning humectant opacifying anti-aging wound healing stimulates collagen production enhances skin elasticity boosts hydration promotes cell proliferation strengthens skin barrier

Science

Mechanism of Action

This synthetic single-chain polypeptide directly provides an Insulin-like Growth Factor (IGF-1 signal) to the skin, activating the crucial cellular AKT pathway, a key mechanism in anti-aging. It works to revitalize aged cells by fostering the formation of new blood vessels from degenerated tissues, thereby facilitating efficient removal of CO2 and metabolic waste products. Topically, RICE SH-OLIGOPEPTIDE-2 significantly boosts the biosynthesis of extracellular matrix components, including hyaluronic acid and collagen, which collectively enhance skin elasticity and density. It stimulates dermal fibroblasts to proliferate and synthesize collagen, while simultaneously encouraging epidermal keratinocyte proliferation and optimizing their differentiation to prevent excessive cell build-up, refine skin texture, and fortify the skin's natural barrier.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

For optimal stability and to ensure its 24-month shelf life from the date of manufacture, RICE SH-OLIGOPEPTIDE-2 must be stored precisely at -20°C to -15°C (in a freezer), protected from light, with its packaging kept air-proofed when not actively in use.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

As an Insulin-like Growth Factor-1 (IGF-1) mimicking peptide, this ingredient introduces considerations relevant to growth factors in skincare. While generally recognized as a safe cosmetic component, growth factors are a complex and debated topic, with recombinant IGF-1 having been correlated with the progression of Melanoma in some research. Individual dermatological reactions should be vigilantly monitored, especially in individuals with predispositions to skin problems, although widespread serious side effects are not commonly reported with its cosmetic use. The CIR has not yet reviewed its safety profile.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

RICE SH-OLIGOPEPTIDE-2 presents a valuable opportunity for advanced skin rejuvenation and repair through its potent growth factor-like actions, offering significant anti-aging and regenerative benefits, though its application should be approached with an informed understanding of general growth factor safety considerations.

Related

Similar Ingredients

Finding similar ingredients…