Science
Mechanism of Action
This peptide operates as a crucial cell-communicating agent, signaling various skin cells to enhance their growth, proliferation, and differentiation. It specifically promotes the regeneration of keratinocytes in the outer skin layer, endothelial cells, and fibroblasts, leading to accelerated skin repair, improved barrier function, and reduced inflammation. Furthermore, it supports the formation of new blood vessels and stimulates the biosynthesis of vital extracellular matrix components such as collagen, elastin, and hyaluronic acid, contributing to significant anti-aging effects and prolonged moisturization.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Due to its medium molecular size and polar nature, specialized delivery systems such as liposomes or nanocarriers are likely essential to optimize skin penetration and bioavailability, ensuring maximum efficacy.
Safety
Safety Profile
While SH-Oligopeptide-1 is generally authorized for cosmetic use, RICE SH-OLIGOPEPTIDE-1 specifically has not undergone a review by the Cosmetic Ingredient Review (CIR) Expert Panel. Active Epidermal Growth Factor (EGF) is classified as a potent pharmaceutical, and although SH-oligopeptide-1 is not a functional EGF, growth factors can potentially induce tumorigenesis if signaling becomes overactive or dysregulated. Therefore, individuals with skin cancer risk factors or psoriasis are advised to use this ingredient with caution, and long-term risks remain undefined.
Your Skin
Skin Compatibility
Our Assessment
Verdict
RICE SH-OLIGOPEPTIDE-1 is an optional ingredient offering advanced regenerative and anti-aging benefits through its EGF-mimetic action, though its use requires careful consideration due to an unreviewed safety profile and the potential implications of growth factor signaling.
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