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Moumoujus

RICE RH-OLIGOPEPTIDE-2.

Questionable / SKIN CONDITIONING

RICE RH-OLIGOPEPTIDE-2 is a precision-engineered signaling peptide, derived from rice, that acts as an Insulin-like Growth Factor 1 (IGF-1) mimetic. It is designed to stimulate profound skin cell renewal and collagen production, fostering healthier, more elastic skin.

Summary

Promotes skin cell renewal Boosts collagen production Enhances skin repair Improves skin elasticity Provides hydration Reduces inflammation Supports skin barrier function Anti-aging

Science

Mechanism of Action

This oligopeptide functions by signaling dermal fibroblasts, promoting their proliferation and the synthesis of crucial extracellular matrix components such as Type I, III, and IV collagen, fibronectin, and glycosaminoglycans. It actively supports the repair and reconstruction of the extracellular matrix and the epidermal-dermal junction (DEJ), while also enhancing wound repair gene expression. Mimicking IGF-1, it stimulates cell growth and regeneration, synergizing with Epidermal Growth Factor (EGF) to boost keratinocyte proliferation. Furthermore, it activates the AKT cellular pathway, critical for anti-aging, and enhances the biosynthesis of hyaluronic acid and other vital extracellular matrix components.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

No specific data regarding dusting practices or thresholds for RICE RH-OLIGOPEPTIDE-2 is available in the provided research.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

As a raw powder, Oligopeptide-2 maintains stability for 24 months when stored between -20 to -15 °C in a freezer, safeguarded from light, and in an air-proofed package. Its growth factor-mimicking properties render it susceptible to destabilization in acidic environments.

Synergies

  • Epidermal Growth Factor (EGF)

Conflicts

  • acidic environments (e.g., Alpha Hydroxy Acids (AHAs), Beta Hydroxy Acids (BHAs))

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

The specific ingredient 'RICE RH-OLIGOPEPTIDE-2' has not been individually assessed by the CIR Expert Panel or the SCCS. While Oligopeptide-2 (sh-Oligopeptide-2/IGF-1) is generally considered well-tolerated and causes minimal irritation, a significant caution exists for growth factor-mimicking peptides like IGF-1, which have been correlated with tumorigenesis or progression, with recombinant IGF-1 specifically linked to Melanoma progression. Regulatory bodies such as the European Cosmetics Regulation approve its general use in cosmetics. Individuals with sensitive skin or known allergies are advised to perform patch testing prior to widespread application.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

While RICE RH-OLIGOPEPTIDE-2 presents a compelling mechanism for skin rejuvenation and repair, its nature as an IGF-1 mimetic, coupled with documented correlations between broader IGF-1 forms and tumorigenesis, raises significant safety questions that require more specific data for this exact ingredient.

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